Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar;88(Suppl 1):28-34.
doi: 10.1007/s12098-020-03621-4. Epub 2021 Feb 2.

Rotavirus Gastroenteritis Hospitalizations Among Under-5 Children in Northern India

Jyoti Sharma  1 , Sanjiv Chaudhary  2 , Mohit Bajaj  2 , Nayana P Nair  3 , Varunkumar Thiyagarajan  3
Affiliations

Rotavirus Gastroenteritis Hospitalizations Among Under-5 Children in Northern India

Jyoti Sharma et al. Indian J Pediatr. 2021 Mar.

Abstract

Objective: To study epidemiological profile, prevalence, and molecular epidemiology of RVGE in hospitalized under-5 children at a tertiary care teaching rural hospital located in sub-Himalayan belt of Northern India.

Methods: This was a hospital-based surveillance study done over 4 y (2016-2019) including under-5 children hospitalized with acute gastroenteritis (AGE). Demographic and clinical parameters were recorded in a pre-designed performa. After consent, stool samples were collected and sent to Christian Medical College (CMC), Vellore for RV screening by enzyme immunoassay (EIA). Each EIA-positive sample was further subjected to G and P typing using published methods.

Results: Out of total 851 included children, rotavirus gastroenteritis (RVGE) was detected in 23.03% (196/851) cases by EIA. The highest incidence for RVGE-positive cases (40.43%) was observed in 2016 with gradual decline over next 3 y. Maximum cases of diarrhea were observed in 12-23 mo age group along with highest rotavirus detection. G3P[8] was most common genotype (46.94%) found, followed by G1P[8] (13.78%), G2P[4] (4.59%), G1P[6] (8.16%) and G9P[4] (3.57%). Mixed genotype was seen in 13.78% of total cases.

Conclusion: This study summarizes the changing trends in the epidemiology of RVGE in Northern India along with the major circulating genotypes postvaccine introduction.

Keywords: Epidemiology; Genotype; Rotavirus gastroenteritis; Under-5 children.

PubMed Disclaimer

References

    1. Troeger C, Khalil IA, Rao PC, et al. Rotavirus vaccination and the global burden of rotavirus diarrhea among children younger than 5 years. JAMA Pediatr [Internet]. 2018;172:958–65. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233802/ . Accessed 24 June 2019.
    1. Troeger C, Forouzanfar M, Rao PC, et al. Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the global burden of disease study 2015. Lancet Infect Dis [internet] Elsevier. 2017;17:909–48. Available at: https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(17)30276... . Accessed 6 Oct 2020. - DOI
    1. Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet (London, England). 2012;379:2151–61. - DOI
    1. Akoua-Koffi C, Akran V, Peenze I, et al. Epidemiological and virological aspects rotavirus diarrhoea in Abidjan, Côte d’Ivoire (1997-2000). Bull Soc Pathol Exot. 2007;100:246–9.
    1. Clark A, Black R, Tate J, et al. Estimating global, regional and national rotavirus deaths in children aged <5 years: current approaches, new analyses and proposed improvements. PLoS One [Internet]. 2017;12. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593200/ . Accessed 15 Sep 2020.

LinkOut - more resources