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. 2021 Mar 2;57(18):2305-2308.
doi: 10.1039/d0cc08162k.

A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

Jing Zhang  1 , Ningning Wang  1 , Qian Li  1 , Yaxin Zhou  1 , Yuxia Luan  1
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A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

Jing Zhang et al. Chem Commun (Camb). .

Abstract

A two-pronged concept combining photodynamic therapy (PDT) and epithelial-mesenchymal transition (EMT) blockade in a minimalist nanoplatform was proposed to combat basal-like breast cancer (BLBC) metastasis. Based on PDT-mediated tumor killing and epalrestat (Epa)-mediated EMT blockade, as-prepared Ce6/Epa nanoparticles prevented BLBC metastasis effectively in vivo, providing a very promising two-pronged strategy against BLBC metastasis.

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