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Editorial
. 2021 May;65(5):576-577.
doi: 10.1111/aas.13788. Epub 2021 Mar 6.

Nitric oxide and COVID-19: Dose, timing and how to administer it might be crucial

Affiliations
Editorial

Nitric oxide and COVID-19: Dose, timing and how to administer it might be crucial

Claes G Frostell et al. Acta Anaesthesiol Scand. 2021 May.
No abstract available

Keywords: COVID-19; acute lung injury; mechanical ventilation; nitric oxide; oxygenation; pulmonary vasoconstriction.

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Conflict of interest statement

The author CF wishes to report financial interest in the development of a new intravenous NO‐donor. The author GH has no conflict of interest to declare.

Comment on

References

    1. Adhikari NKJ, Dellinger RP, Lundin S, et al. Inhaled nitric oxide does not reduce mortality in patients with acute respiratory distress syndrome regardless of severity systematic review and meta‐analysis*. Crit Care Med. 2014;42(2):404‐412. - PubMed
    1. Lotz C, Muellenbach R, Meybohm P, et al. Effects of inhaled nitric oxide in COVID‐19–induced ARDS – Is it worthwhile? Acta Anaesthesiol Scand. 2020. 10.1111/aas.13757 - DOI - PubMed
    1. Gerlach H, Rossaint R, Pappert D, et al. Time‐course and dose‐response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest. 1993;23(8):499‐502. - PubMed
    1. Akaberi D, Krambrich J, Ling J, et al. Mitigation of the replication of SARS‐CoV‐2 by nitric oxide in vitro. Redox Biol. 2020;37:101734. 10.1016/j.redox.2020.101734 - DOI - PMC - PubMed
    1. Safaee Fakhr B, Wiegand SB, Pinciroli R, et al. High concentrations of nitric oxide inhalation therapy in pregnant patients with severe Coronavirus Disease 2019 (COVID‐19). Obstet Gynecol. 2020;136(6):1109‐1113. - PMC - PubMed