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. 2021 Feb 3;16(2):e0245826.
doi: 10.1371/journal.pone.0245826. eCollection 2021.

Patients' experiences and perceptions of Guillain-Barré syndrome: A systematic review and meta-synthesis of qualitative research

Despina Laparidou  1 , Ffion Curtis  2 , Joseph Akanuwe  1 , Jennifer Jackson  3 , Timothy L Hodgson  4 , A Niroshan Siriwardena  1
Affiliations

Patients' experiences and perceptions of Guillain-Barré syndrome: A systematic review and meta-synthesis of qualitative research

Despina Laparidou et al. PLoS One. .

Abstract

Background: Guillain-Barré syndrome (GBS) is an immune-mediated polyradiculoneuropathy, with an incidence of 1-2/100,000 per year. Its severity is variable, ranging from very mild cases with brief weakness to severe paralysis, leading to inability to breathe independently, or even death. Currently there is limited evidence exploring the experiences of GBS patients. The aim of this study was to review patients' experiences and perceptions of GBS and its variants at diagnosis, discharge and during recovery, by conducting a systematic review and thematic meta-synthesis of qualitative studies of patients' experiences of GBS (and its variants).

Methods: We searched twelve electronic databases, supplemented with internet searches and forward and backward citation tracking from the included studies and review articles. Data were synthesised thematically following the Thomas and Harden approach. The CASP Qualitative Checklist was used to assess the quality of the included studies of this review.

Results: Our search strategy identified a total of 5,282 citations and after removing duplicates and excluding citations based on title and abstract, and full-text screening, five studies were included in the review and meta-synthesis; all included studies were considered of acceptable quality. Through constant discussions and an iterative approach, we developed six analytical themes following a patient's journey from suspecting that they had a health problem, through to being hospitalised, experiencing ongoing difficulties, slowly recovering from GBS, adjusting to their new circumstances, and re-evaluating their lives.

Conclusions: Despite the variety of experiences, it was evident from all included studies that being diagnosed with and surviving GBS was a life-changing experience for all participants.

Trial registration: Protocol was registered (CRD42019122199) on the International Prospective Register of Systematic Reviews (http://www.crd.york.ac.uk/PROSPERO).

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Flow diagram of study selection.
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References

    1. Sejvar JJ, Baughman AL, Wise M, Morgan OW. Population incidence of Guillain-Barre syndrome: a systematic review and meta-analysis. Neuroepidemiology. 2011; 36(2): 123–133. 10.1159/000324710 - DOI - PMC - PubMed
    1. National Institute of Neurological Disorders and Stroke. Guillain-Barré Syndrome Fact Sheet 2018; Retrieved October 02, 2019, from https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Fact-She...
    1. Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016; 388: 717–727. 10.1016/S0140-6736(16)00339-1 - DOI - PubMed
    1. Bernsen RAJAM, de Jager AEJ, van der Meche FGA, Suurmeijer TPBM). How Guillain–Barre patients experience their functioning after 1 year. Acta Neurol Scand. 2015; 112: 51–56. 10.1111/j.1600-0404.2005.00429.x - DOI - PubMed
    1. Roodbol J, de Wit MCY, Aarsen FK, Catsman-Berrevoets CE, Jacobs BC. Long-term outcome of Guillain-Barré syndrome in children. J Peripher Nerv Syst. 2014; 19: 121–126. 10.1111/jns5.12068 - DOI - PubMed

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