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Review
. 2021 Feb 1;10(2):214.
doi: 10.3390/antiox10020214.

Impact of Mycotoxins on Animals' Oxidative Status

Alexandros Mavrommatis  1 , Elisavet Giamouri  1 , Savvina Tavrizelou  1 , Maria Zacharioudaki  1 , George Danezis  2   3 , Panagiotis E Simitzis  4 , Evangelos Zoidis  1 , Eleni Tsiplakou  1 , Athanasios C Pappas  1 , Constantinos A Georgiou  2   3 , Kostas Feggeros  1
Affiliations
Review

Impact of Mycotoxins on Animals' Oxidative Status

Alexandros Mavrommatis et al. Antioxidants (Basel). .

Abstract

Mycotoxins appear to be the "Achilles' heel" of the agriculture sector inducing enormous economic losses and representing a severe risk to the health of humans and animals. Although novel determination protocols have been developed and legislation has been implemented within Europe, the side effects of mycotoxins on the homeostatic mechanisms of the animals have not been extensively considered. Feed mycotoxin contamination and the effects on the antioxidant status of livestock (poultry, swine, and ruminants) are presented. The findings support the idea that the antioxidant systems in both monogastrics and ruminants are challenged under the detrimental effect of mycotoxins by increasing the toxic lipid peroxidation by-product malondialdehyde (MDA) and inhibiting the activity of antioxidant defense mechanisms. The degree of oxidative stress is related to the duration of contamination, co-contamination, the synergetic effects, toxin levels, animal age, species, and productive stage. Since the damaging effects of MDA and other by-products derived by lipid peroxidation as well as reactive oxygen species have been extensively studied on human health, a more integrated monitoring mechanism (which will take into account the oxidative stability) is urgently required to be implemented in animal products.

Keywords: Aspergillus; aflatoxin; mycotoxins; ochratoxin A; oxidative stress; poultry; ruminants; swine; zearalenone.

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Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Vila-Donat P., Marín S., Sanchis V., Ramos A. A review of the mycotoxin adsorbing agents, with an emphasis on their multi-binding capacity, for animal feed decontamination. Food Chem. Toxicol. 2018;114:246–259. doi: 10.1016/j.fct.2018.02.044. - DOI - PubMed
    1. Agriopoulou S., Stamatelopoulou E., Varzakas T. Advances in Occurrence, Importance, and Mycotoxin Control Strategies: Prevention and Detoxification in Foods. Foods. 2020;9:137. doi: 10.3390/foods9020137. - DOI - PMC - PubMed
    1. Ayofemi Olalekan Adeyeye S. Aflatoxigenic fungi and mycotoxins in food: A review. Crit. Rev. Food Sci. Nutr. 2019;60:709–721. doi: 10.1080/10408398.2018.1548429. - DOI - PubMed
    1. Rushing B., Selim M. Aflatoxin B1: A review on metabolism, toxicity, occurrence in food, occupational exposure, and detoxification methods. Food Chem. Toxicol. 2014;124:81–100. doi: 10.1016/j.fct.2018.11.047. - DOI - PubMed
    1. Taniwaki M., Pitt J., Magan N. Aspergillus species and mycotoxins: Occurrence and importance in major food commodities. Curr. Opin. Food Sci. 2018;23:38–43. doi: 10.1016/j.cofs.2018.05.008. - DOI

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