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Review
. 2021 Feb 1;10(2):102.
doi: 10.3390/biology10020102.

Systematic Review of Effectiveness of Chitosan as a Biofunctionalizer of Titanium Implants

Nansi López-Valverde  1 , Antonio López-Valverde  1 , Juan Manuel Ramírez  2
Affiliations
Review

Systematic Review of Effectiveness of Chitosan as a Biofunctionalizer of Titanium Implants

Nansi López-Valverde et al. Biology (Basel). .

Abstract

Chitosan is a natural polysaccharide extracted from the shells of crustaceans that has been proposed as a scaffold in tissue engineering. Certain studies have proven a greater osseointegration of titanium surfaces that are functionalized with chitosan. The MEDLINE, CENTRAL, PubMed, and Web of Science databases were electronically searched for in vivo studies. Seven studies met the inclusion criteria. Animal models, implant site, chitosan incorporation methods, and methods of analysis were emphasized. The selected studies were individually discussed regarding the coatings, osseointegration potential, and suitability of the experimental models used, analyzing their limitations. We concluded that chitosan-biofunctionalized titanium surfaces have greater osseointegration capacity that uncoated control titanium alloys.

Keywords: chitosan; coating surface; functionalization; titanium implant.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart.
Figure 2
Figure 2
Graphic of CS incorporation to Ti in included studies.
Figure 3
Figure 3
SYRCLE’s (Systematic Review Centre for Laboratory animal Experimentation) risk of bias tool.
See this image and copyright information in PMC

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References

    1. Civantos A., Martínez-Campos E., Ramos V., Elvira C., Gallardo A., Abarrategi A. Titanium coatings and surface modifications: Toward clinically useful bioactive implants. ACS Biomater. Sci. Eng. 2017;3:1245–1261. doi: 10.1021/acsbiomaterials.6b00604. - DOI - PubMed
    1. Hotchkiss K.M., Sowers K.T., Olivares-Navarrete R. Novel in vitro comparative model of osteogenic and inflammatory cell response to dental implants. Dent. Mater. 2019;35:76–184. doi: 10.1016/j.dental.2018.11.011. - DOI - PubMed
    1. Heller M., Kumar V.V., Pabst A., Brieger J., Al-Nawas B., Kämmerer P.W. Osseous response on linear and cyclic RGD-peptides immobilized on titanium surfaces in vitro and in vivo. J. Biomed. Mater. Res. A. 2018;106:419–427. doi: 10.1002/jbm.a.36255. - DOI - PubMed
    1. Kammerer P.W., Pabst A.M., Dau M., Staedt H., Al-Nawas B., Heller M. Immobilization of BMP-2, BMP-7 and alendronic acid on titanium surfaces: Adhesion, proliferation and differentiation of bone marrow-derived stem cells. J. Biomed. Mater. Res. A. 2020;108:212–220. doi: 10.1002/jbm.a.36805. - DOI - PubMed
    1. Chakravorty N., Ivanovski S., Prasadam I., Crawford R., Oloyede A., Xiao Y. The microRNA expression signature on modified titanium implant surfaces influences genetic mechanisms leading to osteogenic differentiation. Acta Biomater. 2012;8:3516–3523. doi: 10.1016/j.actbio.2012.05.008. - DOI - PubMed

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