Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J Karczewski^{1

2}, Laurent C Francioli^{3

4}, Grace Tiao^{3

4}, Beryl B Cummings^{3

4

5}, Jessica Alföldi^{3

4}, Qingbo Wang^{3

4

6}, Ryan L Collins^{3

6

7}, Kristen M Laricchia^{3

4}, Andrea Ganna^{3

4

8}, Daniel P Birnbaum^{3

4}, Laura D Gauthier⁹, Harrison Brand^{3

7}, Matthew Solomonson^{3

4}, Nicholas A Watts^{3

4}, Daniel Rhodes¹⁰, Moriel Singer-Berk^{3

4}, Eleina M England^{3

4}, Eleanor G Seaby^{3

4}, Jack A Kosmicki^{3

4

6}, Raymond K Walters^{3

4

11}, Katherine Tashman^{3

4

11}, Yossi Farjoun⁹, Eric Banks⁹, Timothy Poterba^{3

4

11}, Arcturus Wang^{3

4

11}, Cotton Seed^{3

4

11}, Nicola Whiffin^{3

4

12

13}, Jessica X Chong¹⁴, Kaitlin E Samocha¹⁵, Emma Pierce-Hoffman^{3

4}, Zachary Zappala^{3

4

16}, Anne H O'Donnell-Luria^{3

4

17

18}, Eric Vallabh Minikel³, Ben Weisburd⁹, Monkol Lek¹⁹, James S Ware^{3

12

13}, Christopher Vittal^{4

11}, Irina M Armean^{3

4}, Louis Bergelson⁹, Kristian Cibulskis⁹, Kristen M Connolly²⁰, Miguel Covarrubias⁹, Stacey Donnelly³, Steven Ferriera²⁰, Stacey Gabriel²⁰, Jeff Gentry⁹, Namrata Gupta^{3

20}, Thibault Jeandet⁹, Diane Kaplan⁹, Christopher Llanwarne⁹, Ruchi Munshi⁹, Sam Novod⁹, Nikelle Petrillo⁹, David Roazen⁹, Valentin Ruano-Rubio⁹, Andrea Saltzman³, Molly Schleicher³, Jose Soto⁹, Kathleen Tibbetts⁹, Charlotte Tolonen⁹, Gordon Wade⁹, Michael E Talkowski^{3

7

21}; Genome Aggregation Database Consortium; Benjamin M Neale^{3

4

11}, Mark J Daly^{3

4

8

11}, Daniel G MacArthur^{22

23

24

25}

Collaborators, Affiliations

Collaborators

Genome Aggregation Database Consortium:
Carlos A Aguilar Salinas, Tariq Ahmad, Christine M Albert, Diego Ardissino, Gil Atzmon, John Barnard, Laurent Beaugerie, Emelia J Benjamin, Michael Boehnke, Lori L Bonnycastle, Erwin P Bottinger, Donald W Bowden, Matthew J Bown, John C Chambers, Juliana C Chan, Daniel Chasman, Judy Cho, Mina K Chung, Bruce Cohen, Adolfo Correa, Dana Dabelea, Mark J Daly, Dawood Darbar, Ravindranath Duggirala, Josée Dupuis, Patrick T Ellinor, Roberto Elosua, Jeanette Erdmann, Tõnu Esko, Martti Färkkilä, Jose Florez, Andre Franke, Gad Getz, Benjamin Glaser, Stephen J Glatt, David Goldstein, Clicerio Gonzalez, Leif Groop, Christopher Haiman, Craig Hanis, Matthew Harms, Mikko Hiltunen, Matti M Holi, Christina M Hultman, Mikko Kallela, Jaakko Kaprio, Sekar Kathiresan, Bong-Jo Kim, Young Jin Kim, George Kirov, Jaspal Kooner, Seppo Koskinen, Harlan M Krumholz, Subra Kugathasan, Soo Heon Kwak, Markku Laakso, Terho Lehtimäki, Ruth J F Loos, Steven A Lubitz, Ronald C W Ma, Daniel G MacArthur, Jaume Marrugat, Kari M Mattila, Steven McCarroll, Mark I McCarthy, Dermot McGovern, Ruth McPherson, James B Meigs, Olle Melander, Andres Metspalu, Benjamin M Neale, Peter M Nilsson, Michael C O'Donovan, Dost Ongur, Lorena Orozco, Michael J Owen, Colin N A Palmer, Aarno Palotie, Kyong Soo Park, Carlos Pato, Ann E Pulver, Nazneen Rahman, Anne M Remes, John D Rioux, Samuli Ripatti, Dan M Roden, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Jeremiah Scharf, Heribert Schunkert, Moore B Shoemaker, Pamela Sklar, Hilkka Soininen, Harry Sokol, Tim Spector, Patrick F Sullivan, Jaana Suvisaari, E Shyong Tai, Yik Ying Teo, Tuomi Tiinamaija, Ming Tsuang, Dan Turner, Teresa Tusie-Luna, Erkki Vartiainen, Marquis P Vawter, James S Ware, Hugh Watkins, Rinse K Weersma, Maija Wessman, James G Wilson, Ramnik J Xavier

Affiliations

¹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. konradk@broadinstitute.org.
² Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. konradk@broadinstitute.org.
³ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
⁵ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
⁶ Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.
⁷ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
⁸ Institute for Molecular Medicine Finland, Helsinki, Finland.
⁹ Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Centre for Translational Bioinformatics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK.
¹¹ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹² National Heart & Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK.
¹³ Cardiovascular Research Centre, Royal Brompton & Harefield Hospitals NHS Trust, London, UK.
¹⁴ Department of Pediatrics, University of Washington, Seattle, WA, USA.
¹⁵ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
¹⁶ Vertex Pharmaceuticals Inc, Boston, MA, USA.
¹⁷ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
¹⁸ Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
¹⁹ Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
²⁰ Broad Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
²¹ Department of Neurology, Harvard Medical School, Boston, MA, USA.
²² Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. d.macarthur@garvan.org.au.
²³ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. d.macarthur@garvan.org.au.
²⁴ Centre for Population Genomics, Garvan Institute of Medical Research, and UNSW Sydney, Sydney, New South Wales, Australia. d.macarthur@garvan.org.au.
²⁵ Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. d.macarthur@garvan.org.au.

PMID: 33536625
PMCID: PMC8064911
DOI: 10.1038/s41586-020-03174-8

Published Erratum

Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

Konrad J Karczewski et al. Nature. 2021 Feb.

. 2021 Feb;590(7846):E53.

doi: 10.1038/s41586-020-03174-8.

Authors

Collaborators

Genome Aggregation Database Consortium:
Carlos A Aguilar Salinas, Tariq Ahmad, Christine M Albert, Diego Ardissino, Gil Atzmon, John Barnard, Laurent Beaugerie, Emelia J Benjamin, Michael Boehnke, Lori L Bonnycastle, Erwin P Bottinger, Donald W Bowden, Matthew J Bown, John C Chambers, Juliana C Chan, Daniel Chasman, Judy Cho, Mina K Chung, Bruce Cohen, Adolfo Correa, Dana Dabelea, Mark J Daly, Dawood Darbar, Ravindranath Duggirala, Josée Dupuis, Patrick T Ellinor, Roberto Elosua, Jeanette Erdmann, Tõnu Esko, Martti Färkkilä, Jose Florez, Andre Franke, Gad Getz, Benjamin Glaser, Stephen J Glatt, David Goldstein, Clicerio Gonzalez, Leif Groop, Christopher Haiman, Craig Hanis, Matthew Harms, Mikko Hiltunen, Matti M Holi, Christina M Hultman, Mikko Kallela, Jaakko Kaprio, Sekar Kathiresan, Bong-Jo Kim, Young Jin Kim, George Kirov, Jaspal Kooner, Seppo Koskinen, Harlan M Krumholz, Subra Kugathasan, Soo Heon Kwak, Markku Laakso, Terho Lehtimäki, Ruth J F Loos, Steven A Lubitz, Ronald C W Ma, Daniel G MacArthur, Jaume Marrugat, Kari M Mattila, Steven McCarroll, Mark I McCarthy, Dermot McGovern, Ruth McPherson, James B Meigs, Olle Melander, Andres Metspalu, Benjamin M Neale, Peter M Nilsson, Michael C O'Donovan, Dost Ongur, Lorena Orozco, Michael J Owen, Colin N A Palmer, Aarno Palotie, Kyong Soo Park, Carlos Pato, Ann E Pulver, Nazneen Rahman, Anne M Remes, John D Rioux, Samuli Ripatti, Dan M Roden, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Jeremiah Scharf, Heribert Schunkert, Moore B Shoemaker, Pamela Sklar, Hilkka Soininen, Harry Sokol, Tim Spector, Patrick F Sullivan, Jaana Suvisaari, E Shyong Tai, Yik Ying Teo, Tuomi Tiinamaija, Ming Tsuang, Dan Turner, Teresa Tusie-Luna, Erkki Vartiainen, Marquis P Vawter, James S Ware, Hugh Watkins, Rinse K Weersma, Maija Wessman, James G Wilson, Ramnik J Xavier

Affiliations

¹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. konradk@broadinstitute.org.
² Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. konradk@broadinstitute.org.
³ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
⁴ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
⁵ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
⁶ Program in Bioinformatics and Integrative Genomics, Harvard Medical School, Boston, MA, USA.
⁷ Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.
⁸ Institute for Molecular Medicine Finland, Helsinki, Finland.
⁹ Data Sciences Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Centre for Translational Bioinformatics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK.
¹¹ Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹² National Heart & Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK.
¹³ Cardiovascular Research Centre, Royal Brompton & Harefield Hospitals NHS Trust, London, UK.
¹⁴ Department of Pediatrics, University of Washington, Seattle, WA, USA.
¹⁵ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
¹⁶ Vertex Pharmaceuticals Inc, Boston, MA, USA.
¹⁷ Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.
¹⁸ Department of Pediatrics, Harvard Medical School, Boston, MA, USA.
¹⁹ Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
²⁰ Broad Genomics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
²¹ Department of Neurology, Harvard Medical School, Boston, MA, USA.
²² Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. d.macarthur@garvan.org.au.
²³ Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. d.macarthur@garvan.org.au.
²⁴ Centre for Population Genomics, Garvan Institute of Medical Research, and UNSW Sydney, Sydney, New South Wales, Australia. d.macarthur@garvan.org.au.
²⁵ Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, Victoria, Australia. d.macarthur@garvan.org.au.

PMID: 33536625
PMCID: PMC8064911
DOI: 10.1038/s41586-020-03174-8

No abstract available

PubMed Disclaimer

Erratum for

The mutational constraint spectrum quantified from variation in 141,456 humans.
Karczewski KJ, Francioli LC, Tiao G, Cummings BB, Alföldi J, Wang Q, Collins RL, Laricchia KM, Ganna A, Birnbaum DP, Gauthier LD, Brand H, Solomonson M, Watts NA, Rhodes D, Singer-Berk M, England EM, Seaby EG, Kosmicki JA, Walters RK, Tashman K, Farjoun Y, Banks E, Poterba T, Wang A, Seed C, Whiffin N, Chong JX, Samocha KE, Pierce-Hoffman E, Zappala Z, O'Donnell-Luria AH, Minikel EV, Weisburd B, Lek M, Ware JS, Vittal C, Armean IM, Bergelson L, Cibulskis K, Connolly KM, Covarrubias M, Donnelly S, Ferriera S, Gabriel S, Gentry J, Gupta N, Jeandet T, Kaplan D, Llanwarne C, Munshi R, Novod S, Petrillo N, Roazen D, Ruano-Rubio V, Saltzman A, Schleicher M, Soto J, Tibbetts K, Tolonen C, Wade G, Talkowski ME; Genome Aggregation Database Consortium; Neale BM, Daly MJ, MacArthur DG. Karczewski KJ, et al. Nature. 2020 May;581(7809):434-443. doi: 10.1038/s41586-020-2308-7. Epub 2020 May 27. Nature. 2020. PMID: 32461654 Free PMC article.

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Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

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Author Correction: The mutational constraint spectrum quantified from variation in 141,456 humans

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