Author Correction: Evaluating drug targets through human loss-of-function genetic variation

Eric Vallabh Minikel^{1

2

3

4

5

6

7

8}, Konrad J Karczewski^{9

10}, Hilary C Martin¹¹, Beryl B Cummings^{9

10

12}, Nicola Whiffin^{9

13}, Daniel Rhodes¹⁴, Jessica Alföldi^{9

10}, Richard C Trembath¹⁵, David A van Heel¹⁶, Mark J Daly^{9

10}; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Stuart L Schreiber^{17

18}, Daniel G MacArthur^{19

20

21

22}

Collaborators, Affiliations

Collaborators

Jessica Alföldi, Irina M Armean, Eric Banks, Louis Bergelson, Kristian Cibulskis, Ryan L Collins, Kristen M Connolly, Miguel Covarrubias, Beryl B Cummings, Mark J Daly, Stacey Donnelly, Yossi Farjoun, Steven Ferriera, Laurent Francioli, Stacey Gabriel, Laura D Gauthier, Jeff Gentry, Namrata Gupta, Thibault Jeandet, Diane Kaplan, Konrad J Karczewski, Kristen M Laricchia, Christopher Llanwarne, Eric V Minikel, Ruchi Munshi, Benjamin M Neale, Sam Novod, Anne H O'Donnell-Luria, Nikelle Petrillo, Timothy Poterba, David Roazen, Valentin Ruano-Rubio, Andrea Saltzman, Kaitlin E Samocha, Molly Schleicher, Cotton Seed, Matthew Solomonson, Jose Soto, Grace Tiao, Kathleen Tibbetts, Charlotte Tolonen, Christopher Vittal, Gordon Wade, Arcturus Wang, Qingbo Wang, James S Ware, Nicholas A Watts, Ben Weisburd, Nicola Whiffin, Carlos A Aguilar Salinas, Tariq Ahmad, Christine M Albert, Diego Ardissino, Gil Atzmon, John Barnard, Laurent Beaugerie, Emelia J Benjamin, Michael Boehnke, Lori L Bonnycastle, Erwin P Bottinger, Donald W Bowden, Matthew J Bown, John C Chambers, Juliana C Chan, Daniel Chasman, Judy Cho, Mina K Chung, Bruce Cohen, Adolfo Correa, Dana Dabelea, Mark J Daly, Dawood Darbar, Ravindranath Duggirala, Josée Dupuis, Patrick T Ellinor, Roberto Elosua, Jeanette Erdmann, Tõnu Esko, Martti Färkkilä, Jose Florez, Andre Franke, Gad Getz, Benjamin Glaser, Stephen J Glatt, David Goldstein, Clicerio Gonzalez, Leif Groop, Christopher Haiman, Craig Hanis, Matthew Harms, Mikko Hiltunen, Matti M Holi, Christina M Hultman, Mikko Kallela, Jaakko Kaprio, Sekar Kathiresan, Bong-Jo Kim, Young Jin Kim, George Kirov, Jaspal Kooner, Seppo Koskinen, Harlan M Krumholz, Subra Kugathasan, Soo Heon Kwak, Markku Laakso, Terho Lehtimäki, Ruth J F Loos, Steven A Lubitz, Ronald C W Ma, Daniel G MacArthur, Jaume Marrugat, Kari M Mattila, Steven McCarroll, Mark I McCarthy, Dermot McGovern, Ruth McPherson, James B Meigs, Olle Melander, Andres Metspalu, Benjamin M Neale, Peter M Nilsson, Michael C O'Donovan, Dost Ongur, Lorena Orozco, Michael J Owen, Colin N A Palmer, Aarno Palotie, Kyong Soo Park, Carlos Pato, Ann E Pulver, Nazneen Rahman, Anne M Remes, John D Rioux, Samuli Ripatti, Dan M Roden, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Jeremiah Scharf, Heribert Schunkert, Moore B Shoemaker, Pamela Sklar, Hilkka Soininen, Harry Sokol, Tim Spector, Patrick F Sullivan, Jaana Suvisaari, E Shyong Tai, Yik Ying Teo, Tuomi Tiinamaija, Ming Tsuang, Teresa Dan Turner, Teresa Tusie-Luna, Erkki Vartiainen, Marquis P Vawter, James S Ware, Hugh Watkins, Rinse K Weersma, Maija Wessman, James G Wilson, Ramnik J Xavier

Affiliations

¹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
² Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
³ Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
⁴ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁵ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA. eminikel@broadinstitute.org.
⁶ Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁷ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁸ Prion Alliance, Cambridge, MA, USA. eminikel@broadinstitute.org.
⁹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
¹¹ Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK.
¹² Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
¹³ National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK.
¹⁴ Centre for Translational Bioinformatics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK.
¹⁵ School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
¹⁶ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
¹⁷ Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁸ Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, USA.
¹⁹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. d.macarthur@garvan.org.au.
²⁰ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. d.macarthur@garvan.org.au.
²¹ Centre for Population Genomics, Garvan Institute of Medical Research and UNSW Sydney, Sydney, Australia. d.macarthur@garvan.org.au.
²² Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, Australia. d.macarthur@garvan.org.au.

PMID: 33536628
PMCID: PMC8064910
DOI: 10.1038/s41586-020-03177-5

Published Erratum

Author Correction: Evaluating drug targets through human loss-of-function genetic variation

Eric Vallabh Minikel et al. Nature. 2021 Feb.

. 2021 Feb;590(7846):E56.

doi: 10.1038/s41586-020-03177-5.

Authors

Collaborators

Jessica Alföldi, Irina M Armean, Eric Banks, Louis Bergelson, Kristian Cibulskis, Ryan L Collins, Kristen M Connolly, Miguel Covarrubias, Beryl B Cummings, Mark J Daly, Stacey Donnelly, Yossi Farjoun, Steven Ferriera, Laurent Francioli, Stacey Gabriel, Laura D Gauthier, Jeff Gentry, Namrata Gupta, Thibault Jeandet, Diane Kaplan, Konrad J Karczewski, Kristen M Laricchia, Christopher Llanwarne, Eric V Minikel, Ruchi Munshi, Benjamin M Neale, Sam Novod, Anne H O'Donnell-Luria, Nikelle Petrillo, Timothy Poterba, David Roazen, Valentin Ruano-Rubio, Andrea Saltzman, Kaitlin E Samocha, Molly Schleicher, Cotton Seed, Matthew Solomonson, Jose Soto, Grace Tiao, Kathleen Tibbetts, Charlotte Tolonen, Christopher Vittal, Gordon Wade, Arcturus Wang, Qingbo Wang, James S Ware, Nicholas A Watts, Ben Weisburd, Nicola Whiffin, Carlos A Aguilar Salinas, Tariq Ahmad, Christine M Albert, Diego Ardissino, Gil Atzmon, John Barnard, Laurent Beaugerie, Emelia J Benjamin, Michael Boehnke, Lori L Bonnycastle, Erwin P Bottinger, Donald W Bowden, Matthew J Bown, John C Chambers, Juliana C Chan, Daniel Chasman, Judy Cho, Mina K Chung, Bruce Cohen, Adolfo Correa, Dana Dabelea, Mark J Daly, Dawood Darbar, Ravindranath Duggirala, Josée Dupuis, Patrick T Ellinor, Roberto Elosua, Jeanette Erdmann, Tõnu Esko, Martti Färkkilä, Jose Florez, Andre Franke, Gad Getz, Benjamin Glaser, Stephen J Glatt, David Goldstein, Clicerio Gonzalez, Leif Groop, Christopher Haiman, Craig Hanis, Matthew Harms, Mikko Hiltunen, Matti M Holi, Christina M Hultman, Mikko Kallela, Jaakko Kaprio, Sekar Kathiresan, Bong-Jo Kim, Young Jin Kim, George Kirov, Jaspal Kooner, Seppo Koskinen, Harlan M Krumholz, Subra Kugathasan, Soo Heon Kwak, Markku Laakso, Terho Lehtimäki, Ruth J F Loos, Steven A Lubitz, Ronald C W Ma, Daniel G MacArthur, Jaume Marrugat, Kari M Mattila, Steven McCarroll, Mark I McCarthy, Dermot McGovern, Ruth McPherson, James B Meigs, Olle Melander, Andres Metspalu, Benjamin M Neale, Peter M Nilsson, Michael C O'Donovan, Dost Ongur, Lorena Orozco, Michael J Owen, Colin N A Palmer, Aarno Palotie, Kyong Soo Park, Carlos Pato, Ann E Pulver, Nazneen Rahman, Anne M Remes, John D Rioux, Samuli Ripatti, Dan M Roden, Danish Saleheen, Veikko Salomaa, Nilesh J Samani, Jeremiah Scharf, Heribert Schunkert, Moore B Shoemaker, Pamela Sklar, Hilkka Soininen, Harry Sokol, Tim Spector, Patrick F Sullivan, Jaana Suvisaari, E Shyong Tai, Yik Ying Teo, Tuomi Tiinamaija, Ming Tsuang, Teresa Dan Turner, Teresa Tusie-Luna, Erkki Vartiainen, Marquis P Vawter, James S Ware, Hugh Watkins, Rinse K Weersma, Maija Wessman, James G Wilson, Ramnik J Xavier

Affiliations

¹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
² Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
³ Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. eminikel@broadinstitute.org.
⁴ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁵ Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA. eminikel@broadinstitute.org.
⁶ Henry and Allison McCance Center for Brain Health, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁷ Department of Neurology, Massachusetts General Hospital, Boston, MA, USA. eminikel@broadinstitute.org.
⁸ Prion Alliance, Cambridge, MA, USA. eminikel@broadinstitute.org.
⁹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁰ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
¹¹ Wellcome Sanger Institute, Hinxton, Cambridgeshire, UK.
¹² Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA.
¹³ National Heart and Lung Institute and MRC London Institute of Medical Sciences, Imperial College London, London, UK.
¹⁴ Centre for Translational Bioinformatics, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London and Barts Health NHS Trust, London, UK.
¹⁵ School of Basic and Medical Biosciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
¹⁶ Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
¹⁷ Chemical Biology and Therapeutics Science Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
¹⁸ Department of Chemistry & Chemical Biology, Harvard University, Cambridge, MA, USA.
¹⁹ Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. d.macarthur@garvan.org.au.
²⁰ Analytical and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. d.macarthur@garvan.org.au.
²¹ Centre for Population Genomics, Garvan Institute of Medical Research and UNSW Sydney, Sydney, Australia. d.macarthur@garvan.org.au.
²² Centre for Population Genomics, Murdoch Children's Research Institute, Melbourne, Australia. d.macarthur@garvan.org.au.

PMID: 33536628
PMCID: PMC8064910
DOI: 10.1038/s41586-020-03177-5

No abstract available

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Erratum for

Evaluating drug targets through human loss-of-function genetic variation.
Minikel EV, Karczewski KJ, Martin HC, Cummings BB, Whiffin N, Rhodes D, Alföldi J, Trembath RC, van Heel DA, Daly MJ; Genome Aggregation Database Production Team; Genome Aggregation Database Consortium; Schreiber SL, MacArthur DG. Minikel EV, et al. Nature. 2020 May;581(7809):459-464. doi: 10.1038/s41586-020-2267-z. Epub 2020 May 27. Nature. 2020. PMID: 32461653 Free PMC article.

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Author Correction: Evaluating drug targets through human loss-of-function genetic variation

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Author Correction: Evaluating drug targets through human loss-of-function genetic variation

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