Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan 18:14:627330.
doi: 10.3389/fnins.2020.627330. eCollection 2020.

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

Karim Fifel  1 , Aleksandar Videnovic  2
Affiliations
Review

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

Karim Fifel et al. Front Neurosci. .

Abstract

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.

Keywords: Alzheimer; Huntington; Parkinson; circadian system; sleep.

PubMed Disclaimer

Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Abbott R. D., Ross G. W., White L. R., Tanner C. M., Masaki K. H., Nelson J. S., et al. (2005). Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 65 1442–1446. - PubMed
    1. Adamczak-Ratajczak A., Kupsz J., Owecki M., Zielonka D., Sowinska A., Checinska-Maciejewska Z., et al. (2017). Circadian rhythms of melatonin and cortisol in manifest Huntington’s disease and in acute cortical ischemic stroke. J. Physiol. Pharmacol. 68 539–546. - PubMed
    1. Alonso-Navarro H., García-Martín E., Agúndez J. A. G., Jiménez-Jiménez F. J. (2019). Association between restless legs syndrome and other movement disorders. Neurology 92 948–964. 10.1212/wnl.0000000000007500 - DOI - PubMed
    1. Amara A. W., Chahine L. M., Videnovic A. (2017). Treatment of sleep dysfunction in Parkinson’s Disease. Curr Treat Options Neurol. 19:26. - PMC - PubMed
    1. Arnulf I., Nielsen J., Lohmann E. (2008). Rapid eye movement sleep disturbances in Huntington disease. Arch. Neurol. 65 482–488. - PubMed