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Review
. 2021 Jan 18:14:627330.
doi: 10.3389/fnins.2020.627330. eCollection 2020.

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

Karim Fifel  1 , Aleksandar Videnovic  2
Affiliations
Review

Circadian and Sleep Dysfunctions in Neurodegenerative Disorders-An Update

Karim Fifel et al. Front Neurosci. .

Abstract

Disruptions of sleep and circadian rhythms are among the most debilitating symptoms in patients with neurodegenerative diseases. Their underlying pathophysiology is multilayered and multifactorial. Recent evidence suggests that sleep and circadian disturbances may influence the neurodegenerative processes as well as be their consequence. In this perspective, we provide an update of the current understanding of sleep and circadian dysregulation in Alzheimer's, Parkinson's, and Huntington's diseases.

Keywords: Alzheimer; Huntington; Parkinson; circadian system; sleep.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

References

    1. Abbott R. D., Ross G. W., White L. R., Tanner C. M., Masaki K. H., Nelson J. S., et al. (2005). Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 65 1442–1446. - PubMed
    1. Adamczak-Ratajczak A., Kupsz J., Owecki M., Zielonka D., Sowinska A., Checinska-Maciejewska Z., et al. (2017). Circadian rhythms of melatonin and cortisol in manifest Huntington’s disease and in acute cortical ischemic stroke. J. Physiol. Pharmacol. 68 539–546. - PubMed
    1. Alonso-Navarro H., García-Martín E., Agúndez J. A. G., Jiménez-Jiménez F. J. (2019). Association between restless legs syndrome and other movement disorders. Neurology 92 948–964. 10.1212/wnl.0000000000007500 - DOI - PubMed
    1. Amara A. W., Chahine L. M., Videnovic A. (2017). Treatment of sleep dysfunction in Parkinson’s Disease. Curr Treat Options Neurol. 19:26. - PMC - PubMed
    1. Arnulf I., Nielsen J., Lohmann E. (2008). Rapid eye movement sleep disturbances in Huntington disease. Arch. Neurol. 65 482–488. - PubMed