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. 2021 Jan 18:7:601854.
doi: 10.3389/fmed.2020.601854. eCollection 2020.

Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker

María de Lourdes Moreno  1 , Diego Sánchez-Muñoz  2 , David Sanders  3 , Alfonso Rodríguez-Herrera  4 , Carolina Sousa  1
Affiliations

Verifying Diagnosis of Refractory Celiac Disease With Urine Gluten Immunogenic Peptides as Biomarker

María de Lourdes Moreno et al. Front Med (Lausanne). .

Abstract

Refractory celiac disease (RCD) involves T-lymphocyte activation despite supposed absence of gluten exposure. Assessing dietary adherence is the cornerstone of RCD diagnosis, but available diagnostic tools fail to monitor gluten-free diet (GFD). A recently acknowledged GFD biomarker is gluten immunogenic peptides (GIP) in urine. This study assessed urine GIP to verify whether RCD patients could be reclassified as "exposed to gluten." Three out of four RCD patients had at least two positive-GIP urine samples in a follow-up of 3 months, demonstrating gluten exposure. Urine GIP may enable the accurate RCD verification and decrease overuse of immunosuppressants, increasing cost effectiveness.

Keywords: celiac disease; gluten immunogenic peptides; gluten-free diet (GFD); refractory celiac disease; urine test.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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References

    1. Testa A, Imperatore N, Rispo A, Rea M, Tortora R, Nardone OM, et al. . Beyond irritable bowel syndrome: the efficacy of the low fodmap diet for improving symptoms in inflammatory bowel diseases and celiac disease. Dig Dis. (2018) 36:271–80. 10.1159/000489487 - DOI - PubMed
    1. Rubio-Tapia A, Murray JA. Classification and management of refractory coeliac disease. Gut. (2010) 59:547–57. 10.1136/gut.2009.195131 - DOI - PMC - PubMed
    1. Penny HA, Baggus EMR, Rej A, Snowden JA, Sanders DS. Non-responsive coeliac disease: a comprehensive review from the NHS England National centre for refractory coeliac disease. Nutrients. (2020) 12:216. 10.3390/nu12010216 - DOI - PMC - PubMed
    1. Al-Bawardy B, Barlow JM, Vasconcelos RN, Kim ST, Bruining DH, Hansel SL, et al. Cross-sectional imaging in refractory celiac disease. Abdom Radiol. (2017) 42:389–95. 10.1007/s00261-016-1032-0 - DOI - PubMed
    1. Zhu J, Mulder CJJ, Dieleman LA. Celiac disease: against the grain in gastroenterology. J Can Assoc Gastroenterol. (2019) 2:161–9. 10.1093/jcag/gwy042 - DOI - PMC - PubMed

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