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Review
. 2021 Jan 9:22:100312.
doi: 10.1016/j.ensci.2021.100312. eCollection 2021 Mar.

Neuropathic pain in Mali: The current situation, comprehensive hypothesis, which therapeutic strategy for Africa?

Youssoufa Maiga  1   2   3 , Oumar Sangho  2 , Fatoumata Konipo  2 , Seybou Diallo  1   2 , Souleymane Dit Papa Coulibaly  2 , Modibo Sangare  2 , Yann Péréon  4 , Bernard Giumelli  5 , Martin Sanou  5 , Awa Coulibaly  1 , Salimata Diallo  1 , Mariam Daou  1 , Zoumana Traoré  6 , Mohamed Albakaye  1 , Hamar A Traoré  2 , Cheick Oumar Guinto  2 , Madani Ouologem  6 , Callixte Kuate-Tegueu  7 , Didier Bouhassira  8 , Robert Cowan  9 , Julien Nizard  3   10
Affiliations
Review

Neuropathic pain in Mali: The current situation, comprehensive hypothesis, which therapeutic strategy for Africa?

Youssoufa Maiga et al. eNeurologicalSci. .

Abstract

Introduction: According to the taxonomy of the International Association for the Study of Pain (IASP 2011), neuropathic pain (NeuP) is defined as "pain caused by a lesion or disease of the somatosensory nervous system". NeuP is currently well-defined clinically, despite a high degree of etiological variation, and it has become a significant public health problem. This work aimed to study the situation regarding NeuP in current practice in Mali, as well as to analyze the therapeutic environment of the patients.

Methodology: This was a retrospective and cross-sectional study, carried out in two phases: (1) compilation of the files of patients according to the ICD-11, over a period of 24 months (2) a second prospective phase regarding the Knowledge, Attitudes, and Practices (KAP) of general practitioners and neurologists in regard to NeuP. The focus of the first phase of the study was the files of the patients who had undergone a consultation at the Gabriel Touré UHC. The second phase of the study focused on the general practitioners (Community Health Centers (comHC) of Bamako) and neurologists (Malian or not).

Results: Over the period of the study, 7840 patients were seen in consultation in the Department of Neurology, of whom 903 for NeuP, thus amounting to a NeuP frequency of 11.5%. Women accounted for 58.9% (532/903), with a sex ratio of 1.4. Using a comparative normal law, the difference in frequency was statistically significant between males and females (p < 10-7) and between two age groups (p 〈10-3). The 49-58 years of age group was represented the most. Diabetic NeuP (21%), lumbar radiculopathies (14%), HIV/AIDS NeuP (13%), and post-stroke NeuP (11%) were the most represented. The survey among the carers revealed: a need for training, a low level of compliance with the therapeutic guidelines, and the use of traditional medicine by the patients.

Discussion/conclusion: This work confirms that NeuP is encountered frequently in current practice, and its optimal management will involve specific training of carers and improvement of access to the medications recommended in this indication. In light of this issue, we revisit the debate regarding the concept of essential medications and the relevance of taking into account effective medications for the treatment of NeuP.

Keywords: Africa; Chronic pain; DN4 questionnaire; Integrative medicine; Mali; Neuropathic pain; Pain management.

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Figures

Fig. 1
Fig. 1
Neuropathic pain typologies in our practice.
Fig. 2
Fig. 2
Distribution of the intensity of the pain according to the neuropathic type.
Fig. 3
Fig. 3
Distribution of the type of pain according to the neuropathic type.
See this image and copyright information in PMC

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