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. 2021 Oct;109(10):1418-1425.
doi: 10.1002/jbm.b.34801. Epub 2021 Feb 3.

Inhibition of oral biofilm formation by zwitterionic nonfouling coating

Fang Sun  1   2 , Hsiang-Chieh Hung  3 , Weishi Yan  4 , Kan Wu  3 , Andy A Shimchuk  2 , Sterling D Gray  2 , Wei He  1   5 , Xuelian Huang  1 , Hai Zhang  1
Affiliations

Inhibition of oral biofilm formation by zwitterionic nonfouling coating

Fang Sun et al. J Biomed Mater Res B Appl Biomater. 2021 Oct.

Abstract

Inhibition of oral biofilm formation is critical to prevent and treat dental caries and periodontal diseases. In this study, we synthesized zwitterionic poly(carboxybetaine) (pCB) based polymer as a nonfouling coating to provide anti-bacterial properties to tooth surfaces. Four catechol derived l-3,4-dihydroxyphenylalanine (DOPA) groups were conjugated to pCB to serve as a surface anchoring group. The pCB-(DOPA)4 polymer was coated on the hydroxyapatite (HA) and enamel samples by simple immersion and characterized by Raman spectroscopy. The nonfouling effectiveness of the pCB based coating was determined by protein adsorption and bacterial adhesion assays. The coating was transparent on sample surfaces. The protein adsorption was significantly reduced to 8.2% and 6.9%, respectively, on pCB-(DOPA)4 coated HA and enamel samples. The pCB-(DOPA)4 -coated samples also demonstrated significantly fewer adhered Pseudomonas aeruginosa, Staphylococcus aureus, and Streptococcus mutants compared to the control. This novel coating material provides an innovative approach to resist biofilm formation on tooth surfaces and has great potential in future dental clinical applications.

Keywords: nonfouling; oral biofilm; surface coating; zwitterionic.

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REFERENCES

    1. Zijnge V, van Leeuwen MB, Degener JE, et al. Oral biofilm architecture on natural teeth. PLoS One. 2010;5(2):e9321.
    1. Aas JA, Paster BJ, Stokes LN, Olsen I, Dewhirst FE. Defining the normal bacterial flora of the oral cavity. J Clin Microbiol. 2005;43(11):5721-5732.
    1. Organization WH. Guideline: Sugars Intake for Adults and Children: World Health Organization; 2015.
    1. Powers JM, Sakaguchi RL, Craig RG. In: Sakaguchi RL, Powers JM, eds. Craig's Restorative Dental Materials. Philadelphia, PA: Elsevier/Mosby; 2012.
    1. Marsh PD, Bradshaw DJ. Dental plaque as a biofilm. J Ind Microbiol. 1995;15(3):169-175.

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