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. 2021 Aug;131(8):1782-1789.
doi: 10.1002/lary.29421. Epub 2021 Feb 4.

Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma

Noritaka Komune  1 , Kuniaki Sato  1 , Takahiro Hongo  1 , Masaru Miyazaki  2 , Shogo Masuda  1 , Kensuke Koike  1 , Ryutaro Uchi  1 , Nana Akagi Tsuchihashi  1 , Teppei Noda  1 , Ryunosuke Kogo  1 , Takahiro Wakasaki  1 , Ryuji Yasumatsu  1 , Takashi Nakagawa  1
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Prognostic Significance of Systemic Inflammatory Response in Cases of Temporal Bone Squamous Cell Carcinoma

Noritaka Komune et al. Laryngoscope. 2021 Aug.

Abstract

Objective/hypothesis: Squamous cell carcinoma (SCC) of the temporal bone is an extremely rare condition. This rarity has led to a delay in the establishment of a standard treatment protocol and adequate staging system. Identification of prognostic markers of this disease from a variety of fields is desirable in the establishment of treatment guidelines for temporal bone SCC. The aim of this study is to assess the prognostic role of inflammation-based prognostic scores in cases of temporal bone SCC.

Study design: Case reries with chart review.

Methods: A total of 71 cases of primary malignancy eligible for curative treatment at a single tertiary medical institute were retrospectively analyzed. Univariate and multivariate regression analyzes were used to investigate the association between the inflammation-based scores and 5-year overall survival.

Results: Univariate Cox regression analyzes showed that a high neutrophil-to-lymphocyte ratio, high platelet-to-lymphocyte ratio, low lymphocyte-to-monocyte ratio, a Glasgow prognostic score of 2, and the systemic inflammation score of 2 were significantly associated with a poor prognosis, as well as a classification of T4 stage, presence of cervical lymph node metastasis, high white blood cell counts, and high C-reactive protein levels. The multivariate analysis showed that a clinical stage of T4 and a systemic inflammation score of 2 were independent prognostic markers.

Conclusions: Inflammation-based prognostic markers are associated with the survival of patients with temporal bone SCC, as well as other head and neck SCCs.

Level of evidence: 4 Laryngoscope, 131:1782-1789, 2021.

Keywords: Temporal bone; inflammatory marker; overall survival; prognostic marker; squamous cell carcinoma.

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References

BIBLIOGRAPHY

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    1. Komune N, Noda T, Kogo R, et al. Primary advanced squamous cell carcinoma of the temporal bone: a single-center clinical study. Laryngoscope 2020;131:E583-E589.
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