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. 2021 Aug;36(4):823-828.
doi: 10.1007/s12250-021-00347-1. Epub 2021 Feb 4.

Human PRV Infection in China: An Alarm to Accelerate Eradication of PRV in Domestic Pigs

Zhenhua Guo  1 , Xin-Xin Chen  1 , Gaiping Zhang  2   3
Affiliations

Human PRV Infection in China: An Alarm to Accelerate Eradication of PRV in Domestic Pigs

Zhenhua Guo et al. Virol Sin. 2021 Aug.
No abstract available

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Conflict of interest statement

All authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Clinical characteristics of PRV infection patients and sero-prevalence of PRV-gE in domestic pigs in China. A Clinical manifestations and prognosis of PRV infection patients in China. At the early stage of infection, fever (100%, 23/23), respiratory signs (72.7%, 16/22) and headache (57.9%, 11/19) were often observed. Then, rapidly progressed to neurological disorders, including seizures/convulsions (95.7%, 22/23) and disturbance of consciousness (95.7%, 22/23). Additionally, 60% (12/20) of the patients had severe visual impairment and 77.3% (17/22) complicated by pulmonary inflammation. All patients were diagnosed with viral encephalitis, except for one who was diagnosed with endophthalmitis alone. The prognosis was very bad: 17.4% (4/23) of the patients died, 17.4% (4/23) developed blindness, 21.7% (5/23) showed severe visual impairment, and 65.2% (15/23) of the patients had severe central nervous system (CNS) symptoms such as persistent vegetative status, memory loss and only could follow simple instructions. B Sero-prevalence of PRV-gE in central China from 2014 to 2019. The positive rate of PRV-gE antibodies ranged from 37.0 to 53.5% and from 68.0 to 78.0% at serum sample level and pig farm level, respectively.
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