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Comment
. 2021 Feb 3;109(3):395-397.
doi: 10.1016/j.neuron.2021.01.012.

NMDA Receptors Singled out for Delayed Activation

Andrew J R Plested  1
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NMDA Receptors Singled out for Delayed Activation

Andrew J R Plested. Neuron. .
Free article

Abstract

In this issue of Neuron, Amin et al. (2021) recorded single NMDA receptors in synaptic-like conditions to reveal how unreliable coupling between agonist binding and channel opening depends on structured linkers. After neurotransmitter binding, a complicated molecular "discussion" ensues, dividing fast synaptic events from delayed openings and failures.

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