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Comparative Study
. 2021 Feb 2;13(2):485.
doi: 10.3390/nu13020485.

Assessing Health-Related Quality of Life in Children with Coeliac Disease: The Italian Version of CDDUX

Marco Crocco  1   2 , Angela Calvi  3 , Paolo Gandullia  3 , Federica Malerba  1   2 , Anthea Mariani  4 , Sonia Di Profio  5 , Barbara Tappino  6 , Stefano Bonassi  7   8
Affiliations
Comparative Study

Assessing Health-Related Quality of Life in Children with Coeliac Disease: The Italian Version of CDDUX

Marco Crocco et al. Nutrients. .

Abstract

We aimed to assess Health-Related Quality of Life (HRQoL) of Italian children and their parents with coeliac disease (CD) using the Coeliac Disease Dutch Questionnaire (CDDUX). The CDDUX underwent a cross-cultural adaptation in a multi-step process, according to international guidelines. A total of 224 children aged between 8-18 years and their parents were prospectively recruited. Cronbach α coefficient was determined as a measure of internal consistency of the questionnaire and inter-children/parent reliability by intraclass correlation coefficient. Univariate and bivariate regression models were used to evaluate correlations between clinical variables and children and parents subclasses of CDDUX and overall mean Paediatric Quality of Life Inventory (PedsQL). The Italian CDDUX proved to be valid and reliable, mean CDDUX total score revealing a neutral evaluation of the quality of life in children 52.6 ± 17.2 and parents 49.5 ± 17.9 (p = 0.07) with strong correlation with PedsQL. The only clinical variable which appeared to affect significantly quality of life both in children and parents was the lower age. A comparison with our results showed remarkable differences in the HRQoL of populations of various nationalities. The Italian version of the CDDUX questionnaire is a simple and reliable tool for assessing the HRQoL in children and adolescents with CD.

Keywords: CDDUX; Health-Related Quality of Life; children; coeliac disease; disease-specific questionnaire; gluten free diet.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Scatter plot of the PedsQL overall mean score and the CDDUX overall mean score. (a) Children r = 0.302, p < 0.001; (b) Parents r = 0.230, p < 0.01.
Figure 2
Figure 2
CDDUX mean and SD obtained by coeliac patients and parents in different countries.
See this image and copyright information in PMC

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