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Case Reports
. 2021 Feb 5;15(1):39.
doi: 10.1186/s13256-020-02602-7.

Conservative management of primary malignant melanoma of the bladder: a case report

Sebastiano Rapisarda  1 , Maida Bada  2 , Andrea Polara  2 , Felice Crocetto  3 , Massimiliano Creta  4 , Francesco Chiancone  5 , Massimo Occhipinti  1 , Rossella Bertoloni  2 , Armando Marciano  1 , Luca Aresu  1 , Arjan Nazaraj  1 , Sara Grosso  1 , Gaetano Grosso  1
Affiliations
Case Reports

Conservative management of primary malignant melanoma of the bladder: a case report

Sebastiano Rapisarda et al. J Med Case Rep. .

Abstract

Background: Primary malignant melanoma (PMM) of the bladder represents a very rare clinic-pathologic entity. Given the rarity of the disease, the best treatment option is not well recognized.

Case presentation: We describe a case of neoplasm of the bladder in a 74 years-old Caucasian man presenting with massive hematuria. Based on clinical, instrumental and histological findings a diagnosis of PMM was made. The patient underwent trans urethral resection of bladder tumor plus intravesical Bacillus Calmette-Guérin.

Conclusions: To make a correct diagnosis, clinical history, endoscopic evaluation, histopathological examination and immunohistochemistry, are necessary. Multidisciplinary evaluation is required to discriminate primary from metastatic malignant melanoma.

Keywords: BCG; Bladder cancer; Bladder melanoma; Cystectomy; TURB.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Endoscopic appearance of primary malignant melanoma of the bladder. The tumor appears as a dark pigmented mass
Fig. 2
Fig. 2
a Hematoxylin/eosin staining (50× magnification) showing a proliferation composed of a mixture of spindle and epithelioid cells with abundant cytoplasm, irregular nuclei, prominent eosinophilic nucleoli and severe pleomorphism; b Immunohistochemical staining (50× magnification) revealing positivity for S100
See this image and copyright information in PMC

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