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. 2021 Feb;62(2):133-140.

Clinical outcomes of dogs with transitional cell carcinoma receiving medical therapy, with and without partial cystectomy

Marcus L Bradbury  1 , Christine M Mullin  1 , Shaban D Gillian  1 , Chick Weisse  1 , Philip J Bergman  1 , Michelle A Morges  1 , Lauren R May  1 , David M Vail  1 , Craig A Clifford  1
Affiliations

Clinical outcomes of dogs with transitional cell carcinoma receiving medical therapy, with and without partial cystectomy

Marcus L Bradbury et al. Can Vet J. 2021 Feb.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Can Vet J. 2021 May;62(5):522. Can Vet J. 2021. PMID: 33967296 Free PMC article.

Abstract
in English, French

The objective of this retrospective study was to evaluate the effects of surgery on outcome for dogs with naturally occurring urinary bladder transitional cell carcinoma. Forty-seven dogs met the inclusion criteria. Thirty-one dogs (Group A) were treated with partial cystectomy and adjunctive medical therapy and 16 dogs (Group B) were treated with medical therapy alone. Overall survival was greater in dogs treated with partial cystectomy and adjunctive medical therapy (498 days for Group A versus 335 days for Group B, hazard ratio 2.5; 95% confidence interval: 1.1 to 5.7; P = 0.026). Progression-free survival was not different between groups (85 days for Group A versus 83 days for Group B; P = 0.663). No prognostic factors were identified for progression-free survival. Due to the many cases in Group A that were lost to follow-up, time-to-event survival analysis was performed. No significant difference in overall survival was noted, and no prognostic factors were identified in the time-to-event analysis. Prospective, randomized studies are needed to determine the role of partial cystectomy in the treatment of transitional cell carcinoma.

Résultats cliniques des chiens atteints d’un carcinome à cellules transitionnelles recevant un traitement médical, avec et sans cystectomie partielle. L’objectif de cette étude rétrospective était d’évaluer les effets de la chirurgie sur les résultats chez des chiens atteints d’un carcinome à cellules transitionnelles de la vessie d’origine naturelle. Quarante-sept chiens répondaient aux critères d’inclusion. Trente et un chiens (Groupe A) ont été traités par cystectomie partielle et traitement médical d’appoint et 16 chiens (Groupe B) ont été traités par thérapie médicale seule. La survie globale était plus élevée chez les chiens traités par cystectomie partielle et traitement médical d’appoint (498 jours pour le Groupe A contre 335 jours pour le Groupe B, rapport de risque de 2,5; intervalle de confiance à 95 % : 1,1 à 5,7; P = 0,026). La survie sans progression n’était pas différente entre les groupes (85 jours pour le Groupe A contre 83 jours pour le Groupe B; P = 0,663). Aucun facteur pronostique n’a été identifié pour la survie sans progression. En raison des nombreux cas dans le Groupe A qui ont été perdus de vue lors du suivi, une analyse du temps de survie a été realisée. Aucune différence significative dans la survie globale n’a été notée et aucun facteur pronostique n’a été identifié dans l’analyse du temps de survive. Des études prospectives randomisées sont nécessaires pour déterminer le rôle de la cystectomie partielle dans le traitement du carcinome à cellules transitionnelles.(Traduit par Dr Serge Messier).

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Figures

Figure 1
Figure 1
Kaplan–Meier curve comparing the progression-free survival for dogs treated with partial cystectomy and medical therapy (Surgery — solid line) versus those treated with medical therapy alone (No surgery — dashed line). Vertical tick marks indicate censored cases.
Figure 2
Figure 2
Kaplan–Meier curve comparing the overall survival for dogs treated with partial cystectomy and medical therapy (Surgery — solid line) versus those treated with medical therapy alone (No surgery — dashed line). Hazard ratio (HR); 95% CI (confidence interval). Vertical tick marks indicate censored cases.
See this image and copyright information in PMC

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