Electrospun Nanofibers for Cancer Therapy

Huanhuan Luo^{1

2}, Tianyang Jie¹, Li Zheng³, Chenglong Huang², Gang Chen², Wenguo Cui⁴

Affiliations

¹ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
³ The central laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
⁴ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wgcui80@hotmail.com.

PMID: 33543460
DOI: 10.1007/978-3-030-58174-9_8

Review

Electrospun Nanofibers for Cancer Therapy

Huanhuan Luo et al. Adv Exp Med Biol. 2021.

. 2021:1295:163-190.

doi: 10.1007/978-3-030-58174-9_8.

Authors

Huanhuan Luo^{1

2}, Tianyang Jie¹, Li Zheng³, Chenglong Huang², Gang Chen², Wenguo Cui⁴

Affiliations

¹ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
² Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials, Department of Orthopaedics, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
³ The central laboratory, The Second Affiliated Hospital of Jiaxing University, Jiaxing, China.
⁴ Shanghai Institute of Traumatology and Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wgcui80@hotmail.com.

PMID: 33543460
DOI: 10.1007/978-3-030-58174-9_8

Abstract

Lately, a remarkable progress has been recorded in the field of electrospinning for the preparation of numerous types of nanofiber scaffolds. These scaffolds present some remarkable features including high loading capacity and encapsulation efficiency, superficial area and porosity, potential for modification, structure for the co-delivery of various therapies, and cost-effectiveness. Their present and future applications for cancer diagnosis and treatment are promising and pioneering. In this chapter we provide a comprehensive overview of electrospun nanofibers (ESNFs) applications in cancer diagnosis and treatment, covering diverse types of drug-loaded electrospun nanofibers.

Keywords: Biosensors; Cancer diagnosis; Cell capture; Chemosensors; Drug carrier; Electrospun fibers; Gas sensors; Immunosensor; Immunotherapy; Intelligent cancer therapy; Switchable drug release; Synergistic therapy.

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References

1. Qin, S. Y., Zhang, A. Q., Cheng, S. X., Rong, L., & Zhang, X. Z. (2017). Drug self-delivery systems for cancer therapy. Biomaterials, 112, 234–247. - PubMed - DOI - PMC
1. Singh, M., Kundu, S., Reddy, M. A., Sreekanth, V., Motiani, R. K., Sengupta, S., Srivastava, A., & Bajaj, A. (2014). Injectable small molecule hydrogel as a potential nanocarrier for localized and sustained in vivo delivery of doxorubicin. Nanoscale, 6(21), 12849–12855. - PubMed - DOI - PMC
1. Cho, K., Wang, X., Nie, S., Chen, Z. G., & Shin, D. M. (2008). Therapeutic nanoparticles for drug delivery in cancer. Clinical Cancer Research, 14(5), 1310–1316. - PubMed - DOI - PMC
1. Li, Y., Zhou, Y., Gu, T., Wang, G., Ren, Z., Weng, W., Li, X., Han, G., & Mao, C. (2016). A multifunctional Nanocrystalline CaF2:Tm,Yb@mSiO2 system for dual-triggered and optically monitored doxorubicin delivery. Particle and Particle Systems Characterization, 33(12), 896–905. - PubMed - DOI - PMC
1. Li, Y., Zhou, Y., Li, X., Sun, J., Ren, Z., Wen, W., Yang, X., & Han, G. (2016). A facile approach to Upconversion crystalline CaF2:Yb(3+),Tm(3+)@mSiO2 nanospheres for tumor therapy. RSC Advances, 6(44), 38365–38370. - PubMed - PMC - DOI

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Electrospun Nanofibers for Cancer Therapy

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Electrospun Nanofibers for Cancer Therapy

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