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Review
. 2021 Apr;78(8):3791-3801.
doi: 10.1007/s00018-021-03772-3. Epub 2021 Feb 5.

At the heart of mitochondrial quality control: many roads to the top

Roberta A Gottlieb  1 , Honit Piplani  2 , Jon Sin  2 , Savannah Sawaged  2 , Syed M Hamid  2 , David J Taylor  2 , Juliana de Freitas Germano  2
Affiliations
Review

At the heart of mitochondrial quality control: many roads to the top

Roberta A Gottlieb et al. Cell Mol Life Sci. 2021 Apr.

Abstract

Mitochondrial quality control depends upon selective elimination of damaged mitochondria, replacement by mitochondrial biogenesis, redistribution of mitochondrial components across the network by fusion, and segregation of damaged mitochondria by fission prior to mitophagy. In this review, we focus on mitochondrial dynamics (fusion/fission), mitophagy, and other mechanisms supporting mitochondrial quality control including maintenance of mtDNA and the mitochondrial unfolded protein response, particularly in the context of the heart.

Keywords: Cardiac; Fission; Fusion; Mitochondria; Mitophagy.

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Figures

Fig. 1
Fig. 1
Surface area: volume relationship in mitochondria
Fig. 2
Fig. 2
Canonical and alternative mitophagy pathways
See this image and copyright information in PMC

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