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Observational Study
. 2021 Apr;46(4):404-407.
doi: 10.1139/apnm-2020-1005. Epub 2021 Feb 5.

Metabolic flexibility during late pregnancy is associated with neonatal adiposity

Rachel A Tinius  1 , Maire M Blankenship  2 , Karen E Furgal  3 , W Todd Cade  4 , Cathryn Duchette  1 , Kevin J Pearson  5 , Jill M Maples  6
Affiliations
Observational Study

Metabolic flexibility during late pregnancy is associated with neonatal adiposity

Rachel A Tinius et al. Appl Physiol Nutr Metab. 2021 Apr.

Abstract

The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of "metabolic flexibility". Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = -0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319. Novelty: This is the first study to link maternal metabolic flexibility, body mass index, and insulin resistance during pregnancy to neonatal adiposity at parturition.

Keywords: déplacement du substrat; enceinte; lipid oxidation; neonates; nouveau-nés; oxydation lipidique; pregnant; substrate shifting.

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Conflict of interest statement

Competing Interests: The authors declare there are no competing interests.

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