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Case Reports
. 2020 Apr-Jun;61(2):563-567.
doi: 10.47162/RJME.61.2.28.

Oral lichen planus - case report

Cristian Sebastian Vlad  1 , Daliborca Cristina Vlad, Roxana Popescu, Veronica Mădălina Borugă, Sînziana Luminiţa Istrate, Corina Flangea, Beatrice Giorgiana Barac, Ioana Maria Maliţa, Simona Ioana Şipoş, Flavia Baderca
Affiliations
Case Reports

Oral lichen planus - case report

Cristian Sebastian Vlad et al. Rom J Morphol Embryol. 2020 Apr-Jun.

Abstract

This paper presents the case of a 58-year-old heavy smoker female who came to our clinic with acute pain, as well as mastication and feeding difficulties. The macroscopic examination revealed oral erosive lesions and ulcerations. The polymorphic aspect of the lesions required the differential diagnosis of oral erythroplakia or carcinoma, which were excluded by biopsy. At the same time, we assessed the expression of S100 protein, Ki67 and the cluster of differentiation (CD) 4, CD8 (T-cell) and CD20 (B-cell) immune cell markers by immunohistochemical analysis. As a result, after the clinical and pathological assessment, the diagnosis of oral lichen planus was established, and a therapy plan was conducted. We observed a favorable clinical evolution after the administration of corticosteroids and immunomodulatory agents.

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Conflict of interest statement

The authors declare that they have no conflict of interests.

Figures

Figure 1
Figure 1
Erosive gingivitis on the left upper arch
Figure 2
Figure 2
Leukoplakia plaque on inside of the right cheek
Figure 3
Figure 3
Wickham striae on inside of the right cheek
Figure 4
Figure 4
Leukoplakia patches on the anterior side of the tongue
Figure 5
Figure 5
Labial mucosa, thickened epithelium with irregular acanthosis, hypergranulosis and hyperparakeratosis. HE staining, ×100
Figure 6
Figure 6
Labial mucosa, band-like infiltrate of inflammatory cells beneath the squamous cell epithelium. HE staining, ×200
Figure 7
Figure 7
Labial mucosa, exocytosis of inflammatory cells, with perturbation of basement membrane integrity. HE staining, ×400
Figure 8
Figure 8
Labial mucosa: negative immunohistochemical reaction for CD4. Immunostaining with anti-CD4 antibody, ×200. CD4: Cluster of differentiation 4
Figure 9
Figure 9
Labial mucosa: positive immunohistochemical reaction for CD8 in 35% of inflammatory infiltrate cells, with the presence of some positive T-cells between epithelial cells. Immunostaining with anti-CD8 antibody, ×200. CD8: Cluster of differentiation 8
Figure 10
Figure 10
Labial mucosa: positive immunohistochemical reaction for CD20 in 5% of inflammatory cells. Immunostaining with anti-CD20 antibody, ×200. CD20: Cluster of differentiation 20
Figure 11
Figure 11
Labial mucosa: positive immunostaining for S100 protein in some Langerhans cells. Immunostaining with anti-S100 antibody, ×100
Figure 12
Figure 12
Labial mucosa: immunostaining for anti-Ki67 antibody restricted to the basal layer keratinocytes. Immunostaining with anti-Ki67 antibody, ×200
See this image and copyright information in PMC

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References

    1. Gheorghe C, Mihai L, Parlatescu I, Tovaru S. Association of oral lichen planus with chronic C hepatitis. Review of the data in literature. Maedica (Bucharest) 2014;9(1):98–103. - PMC - PubMed
    1. Tampa M, Caruntu C, Mitran M, Mitran C, Sarbu I, Rusu LC, Matei C, Constantin C, Neagu M, Georgescu SR. Markers of oral lichen planus malignant transformation. Dis Markers. 2018;2018:1959506–1959506. - PMC - PubMed
    1. Roopashree MR, Gondhalekar RV, Shashikanth MC, George J, Thippeswamy SH, Shukla A. Pathogenesis of oral lichen planus - a review. J Oral Pathol Med. 2010;39(10):729–734. - PubMed
    1. Vijay P, Pardhe N, Singhal I, Punga R, Singh H. Oral lichen planus: a case report. Int J Oral Health Med Res. 2016;3(3):54–55. http://www.ijohmr.com/upload/Oral%20Lichen%20Planus-%20A%20Case%20Report...
    1. Chiriac A, Foia L, Chiriac AE, Ancuţa C, Manea P, Profire L, Filip F. Lichen planus secondary complications associated with the use of biologic therapy for rheumatoid arthritis. Rom J Morphol Embryol. 2013;54(3 Suppl):829–831. - PubMed

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