Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Jul;74(1):513-515.
doi: 10.1002/hep.31736. Epub 2021 Jun 18.

Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening

Affiliations

Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening

Ian M Copple et al. Hepatology. 2021 Jul.
No abstract available

PubMed Disclaimer

Similar articles

Cited by

References

    1. Monroe JJ, Tanis KQ, Podtelezhnikov AA, Nguyen T, Machotka SV, Lynch D, et al. Application of a rat liver drug bioactivation transcriptional response assay early in drug development that informs chemically reactive metabolite formation and potential for drug-induced liver injury. Toxicol Sci 2020;177:281-299.
    1. Podtelezhnikov AA, Monroe JJ, Aslamkhan AG, Pearson K, Qin C, Tamburino AM, et al. Quantitative transcriptional biomarkers of xenobiotic receptor activation in rat liver for the early assessment of drug safety liabilities. Toxicol Sci 2020;175:98-112.
    1. Kang W, Podtelezhnikov AA, Tanis KQ, Pacchione S, Su M, Bleicher KB, et al. Development and application of a transcriptomic signature of bioactivation in an advanced in vitro liver model to reduce drug-induced liver injury risk early in the pharmaceutical pipeline. Toxicol Sci 2020;177:121-139.
    1. Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, et al. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: Implications for prediction of drug-induced liver injury. Arch Toxicol 2019;93:385-399.
    1. Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, et al. Reproducing human and cross-species drug toxicities using a Liver-Chip. Sci Transl Med 2019;11:eaax5516.

LinkOut - more resources