Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening
- PMID: 33544908
- DOI: 10.1002/hep.31736
Gene Signatures Reduce the Stress of Preclinical Drug Hepatotoxicity Screening
Similar articles
-
In vitro transcriptomic prediction of hepatotoxicity for early drug discovery.J Theor Biol. 2011 Dec 7;290:27-36. doi: 10.1016/j.jtbi.2011.08.009. Epub 2011 Aug 27. J Theor Biol. 2011. PMID: 21884709 Free PMC article.
-
"Drug-Induced Liver Injury Clinical Consortia: a global research response for a worldwide health challenge".Expert Opin Drug Metab Toxicol. 2016 Jun;12(6):589-93. doi: 10.1517/17425255.2016.1141896. Epub 2016 Feb 6. Expert Opin Drug Metab Toxicol. 2016. PMID: 26820043 No abstract available.
-
Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.Toxicol Sci. 2016 Jul;152(1):214-29. doi: 10.1093/toxsci/kfw078. Epub 2016 May 4. Toxicol Sci. 2016. PMID: 27208088
-
Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.Expert Opin Drug Discov. 2017 Feb;12(2):201-211. doi: 10.1080/17460441.2017.1271784. Epub 2016 Dec 21. Expert Opin Drug Discov. 2017. PMID: 27936962 Review.
-
Evolution of Experimental Models of the Liver to Predict Human Drug Hepatotoxicity and Efficacy.Clin Liver Dis. 2017 Feb;21(1):197-214. doi: 10.1016/j.cld.2016.08.013. Clin Liver Dis. 2017. PMID: 27842772 Free PMC article. Review.
Cited by
-
Mechanism of Action of Dihydroquercetin in the Prevention and Therapy of Experimental Liver Injury.Molecules. 2024 Jul 27;29(15):3537. doi: 10.3390/molecules29153537. Molecules. 2024. PMID: 39124941 Free PMC article. Review.
-
Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity.Arch Toxicol. 2023 Aug;97(8):2291-2302. doi: 10.1007/s00204-023-03522-3. Epub 2023 Jun 9. Arch Toxicol. 2023. PMID: 37296313 Free PMC article.
References
-
- Monroe JJ, Tanis KQ, Podtelezhnikov AA, Nguyen T, Machotka SV, Lynch D, et al. Application of a rat liver drug bioactivation transcriptional response assay early in drug development that informs chemically reactive metabolite formation and potential for drug-induced liver injury. Toxicol Sci 2020;177:281-299.
-
- Podtelezhnikov AA, Monroe JJ, Aslamkhan AG, Pearson K, Qin C, Tamburino AM, et al. Quantitative transcriptional biomarkers of xenobiotic receptor activation in rat liver for the early assessment of drug safety liabilities. Toxicol Sci 2020;175:98-112.
-
- Kang W, Podtelezhnikov AA, Tanis KQ, Pacchione S, Su M, Bleicher KB, et al. Development and application of a transcriptomic signature of bioactivation in an advanced in vitro liver model to reduce drug-induced liver injury risk early in the pharmaceutical pipeline. Toxicol Sci 2020;177:121-139.
-
- Copple IM, den Hollander W, Callegaro G, Mutter FE, Maggs JL, Schofield AL, et al. Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: Implications for prediction of drug-induced liver injury. Arch Toxicol 2019;93:385-399.
-
- Jang KJ, Otieno MA, Ronxhi J, Lim HK, Ewart L, Kodella KR, et al. Reproducing human and cross-species drug toxicities using a Liver-Chip. Sci Transl Med 2019;11:eaax5516.
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical