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Comment
. 2021 Feb 4;81(3):423-425.
doi: 10.1016/j.molcel.2021.01.001.

NLRP1: a jack of all trades, or a master of one?

Daniel A Bachovchin  1
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NLRP1: a jack of all trades, or a master of one?

Daniel A Bachovchin. Mol Cell. .
Free article

Abstract

Recent studies provide evidence that two chemically and mechanistically distinct signals activate the human NLRP1 inflammasome, challenging the concept that it-like other mammalian inflammasomes characterized thus far-evolved to detect and respond to a single danger-associated molecular pattern.

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