Membrane Tension Locks In Pluripotency

Jonathon M Muncie¹, Valerie M Weaver²

Affiliations

¹ Gladstone Institutes, San Francisco, CA 94158, USA.
² Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Comprehensive Cancer Center, Helen Diller Family Cancer Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, Department of Bioengineering and Therapeutic Sciences, Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: valerie.weaver@ucsf.edu.

PMID: 33545073
DOI: 10.1016/j.stem.2021.01.008

Free article

Comment

Membrane Tension Locks In Pluripotency

Jonathon M Muncie et al. Cell Stem Cell. 2021.

Free article

. 2021 Feb 4;28(2):175-176.

doi: 10.1016/j.stem.2021.01.008.

Authors

Jonathon M Muncie¹, Valerie M Weaver²

Affiliations

¹ Gladstone Institutes, San Francisco, CA 94158, USA.
² Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Comprehensive Cancer Center, Helen Diller Family Cancer Research Center, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Anatomy, Department of Bioengineering and Therapeutic Sciences, Department of Radiation Oncology, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: valerie.weaver@ucsf.edu.

PMID: 33545073
DOI: 10.1016/j.stem.2021.01.008

Abstract

In this issue of Cell Stem Cell, De Belly et al. (2021) and Bergert et al. (2021) reveal that membrane tension regulates the pluripotent state via endocytosis-mediated ERK signaling. These findings advance our understanding of naive pluripotency and highlight how cell mechanics are intertwined with molecular signaling to drive cell fate decisions.

PubMed Disclaimer

Comment on

Cell Surface Mechanics Gate Embryonic Stem Cell Differentiation.
Bergert M, Lembo S, Sharma S, Russo L, Milovanović D, Gretarsson KH, Börmel M, Neveu PA, Hackett JA, Petsalaki E, Diz-Muñoz A. Bergert M, et al. Cell Stem Cell. 2021 Feb 4;28(2):209-216.e4. doi: 10.1016/j.stem.2020.10.017. Epub 2020 Nov 17. Cell Stem Cell. 2021. PMID: 33207217 Free PMC article.
Membrane Tension Gates ERK-Mediated Regulation of Pluripotent Cell Fate.
De Belly H, Stubb A, Yanagida A, Labouesse C, Jones PH, Paluch EK, Chalut KJ. De Belly H, et al. Cell Stem Cell. 2021 Feb 4;28(2):273-284.e6. doi: 10.1016/j.stem.2020.10.018. Epub 2020 Nov 19. Cell Stem Cell. 2021. PMID: 33217323 Free PMC article.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- scite Smart Citations
Miscellaneous
- NCI CPTAC Assay Portal

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Membrane Tension Locks In Pluripotency

Affiliations

Membrane Tension Locks In Pluripotency

Authors

Affiliations

Abstract

Comment on

Publication types

MeSH terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Miscellaneous