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Comment
. 2021 Feb 4;28(2):177-179.
doi: 10.1016/j.stem.2020.11.016.

NSCs: Sentinel Cells of the Brain

Stefano Pluchino  1 , Alexandra M Nicaise  2
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NSCs: Sentinel Cells of the Brain

Stefano Pluchino et al. Cell Stem Cell. .
Free article

Abstract

Adult neural stem cells (NSCs) have the ability to oscillate between activated and dormant states in response to extrinsic regulators. In this issue of Cell Stem Cell, Belenguer et al. (2020) identify a direct role for systemic TNF-α, which acts through its receptors TNFRII and TNFRI as a regulator of NSC activation and a return to quiescence, respectively.

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Conflict of interest statement

Declaration of Interests S.P. is co-founder and CSO at CITC Ltd. and iSTEM Therapeutics and co-founder and Non-executive Director (NED) at Asitia Therapeutics. A.N. is an advisor for iSTEM Therapeutics.

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