Comment

. 2021 May;82(5):186-230.

doi: 10.1016/j.jinf.2021.01.026. Epub 2021 Feb 3.

High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Sarah Tubiana¹, Charles Burdet², Nadhira Houhou³, Michael Thy⁴, Pauline Manchon⁵, François Blanquart⁶, Charlotte Charpentier⁷, Jérémie Guedj⁸, Loubna Alavoine⁴, Sylvie Behillil⁹, Anne Leclercq¹⁰, Jean-Christophe Lucet¹¹, Yazdan Yazdanpanah¹², Mikaël Attia¹³, Caroline Demeret¹⁴, Thierry Rose¹⁵, Julia Anna Bielicki¹⁶, Patricia Bruijning-Verhagen¹⁷, Herman Goossens¹⁸, Diane Descamps⁷, Sylvie van der Werf⁹, Bruno Lina¹⁹, Xavier Duval²⁰; CoVCONTACT study group; Principal investigator; Sponsor: Inserm

Collaborators, Affiliations

Collaborators

Xavier Duval, Charles Burdet, Xavier Duval, Bruno Lina, Sarah Tubiana, Sylvie Van Der Werf, Fanny Abad, Dominique Abry, Loubna Alavoine, Jean-Sébastien Allain, Karline Amiel-Taieb, Pierre Audoin, Shana Augustin, Sandrine Ayala, Hélène Bansard, Fréderique Bertholon, Nolwenn Boissel, Elisabeth Botelho-Nevers, Kévin Bouiller, Marilou Bourgeon, Mathilde Boutrou, Lysiane Brick, Léa Bruneau, Eric Caumes, Agnès Chabouis, Eric Chan Thien, Catherine Chirouze, Bruno Coignard, Yolande Costa, Virginie Costenoble, Sylvie Cour, Claire Cracowski, Luc Cracowski Jean, Dominique Deplanque, Stéphane Dequand, Mireille Desille-Dugast, Maxime Desmarets, Maelle Detoc, Marie Dewitte, Felix Djossou, Jean-Luc Ecobichon, Elise Elrezzi, William Faurous, Viviane Fortuna, Julie Fouchard, Emilie Gantier, Céline Gautier, Patrick Gerardin, Sandrine Gerset, Marie Gilbert, Valérie Gissot, Francis Guillemin, Cédric Hartard, Béatrice Hazevis, Didier Hocquet, Enkelejda Hodaj, Emila Ilic-Habensus, Jeudy A, Helene Jeulin, Maty Kane, Emmanuelle Kasprzyk, John Kikoine, Fabrice Laine, Bruno Laviolle, David Lebeaux, Anne Leclercq, Eric Ledru, Benjamin Lefevre, Carole Legoas, Amélie Legrand, Karine Legrand, Jonathan Lehacaut, Claire Lehur, Dalila Lemouche, Quentin Lepiller, Sévérine Lepuil, Estelle Letienne, Aude Lucarelli, Jean-Christophe Lucet, Isabelle Madeline, Adrien Maillot, Catherine Malapate, Denis Malvy, Milica Mandic, Solène Marty-Quinternet, Mohamed Meghadecha, Mayka Mergeay-Fabre, Pauline Mespoulhe, Alexandre Meunier, Maria-Claire Migaud, Justina Motiejunaite, Gay Nathalie, Duc Nguyen, Soumaya Oubbea, Maïder Pagadoy, Adeline Paris, Christophe Paris, Christine Payet, Nathan Peiffer-Smadja, Lucas Perez, Pauline Perreau, Nathalie Pierrez, Thierry Pistone, Andreea Postolache, Patrick Rasoamanana, Cécile Reminiac, Jade Rexah, Elise Roche-Gouanvic, Alexandra Rousseau, Betty Schoemaecker, Sandrine Simon, Catherine Soler, Stéphanie Somers, Khaly Sow, Bernard Tardy, Zaven Terzian, Michael Thy, Anne Tournier, Sandrine Tyrode, Charline Vauchy, Renaud Verdon, Pauline Vernet, Valérie Vignali, Nawal Waucquier, Charles Burdet, Huong Do Thi Thu, Cédric Laouénan, France Mentre, Manchon Pauline, Sarah Tubiana, Aline Dechanet, Sophie Letrou, Caroline Quintin, Wahiba Frezouls, Quentin Le Hingrat, Nadhira Houhou, Florence Damond, Dianes Descamps, Charlotte Charpentier, Benoit Visseaux, Astrid Vabret, Bruno Lina, Maud Bouscambert, Sylvie Van Der Werf, Sylvie Behillil, Laurence Gaillanne, Nabil Benmalek, Mikael Attia, Marion Barbet, Caroline Demeret, Thierry Rose, Stéphane Petres, Nicolas Escriou, Marion Barbet, Stéphane Petres, Nicolas Escriou, Sophie Goyard, Ouifiya Kafif, Valentine Piquard, Sarah Tubiana, Bruno Coignard²¹, Alexandra Mailles²¹, Anne Simondon²², Marion Dreyere²², Bruno Morel²², Thiphaine Vesval²², Karine Amat, Douae Ammour, Khadija Aqourras, Sandrine Couffin-Cadiergues, Christelle Delmas, Vristi Desan, Michel Doute Jean, Hélène Esperou, Samia Hendou, Christelle Kouakam, Guillaume Le Meut, Soizic Lemestre, Nicolas Leturque, Emmanuelle Marcoul, Solange Nguefang, Layidé Roufai, Laurent Abel, Sophie Caillat-Zucman

Affiliations

¹ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Centre de Ressources Biologiques, F-75018 Paris, France.
² AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Département d'Epidémiologie, Biostatistique et Recherche, F-75018 Paris, France.
³ AP-HP, Hôpital Bichat, Laboratoire de Virologie, F-75018 Paris, France.
⁴ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France.
⁵ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; AP-HP, Hôpital Bichat, Département d'Epidémiologie, Biostatistique et Recherche, F-75018 Paris, France.
⁶ Université de Paris, IAME, INSERM, F-75018 Paris, France; Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France.
⁷ Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Laboratoire de Virologie, F-75018 Paris, France.
⁸ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France.
⁹ Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France.
¹⁰ AP-HP, Beaujon Hospital, Direction des soins, F-92118 Clichy, France.
¹¹ Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Equipe de Prévention du Risque Infectieux, F-75018 Paris, France.
¹² Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et tropicales, F-75018 Paris, France.
¹³ Physique des fonctions biologiques, CNRS UMR3738, Institut Pasteur, Paris, France.
¹⁴ Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.
¹⁵ Biologie cellulaire des lymphocytes, INSERM - U1221, Department of Immunology, Institut Pasteur, Paris, France.
¹⁶ Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St George's University of London, London SW17 0RE, United Kingdom; Paediatric Pharmacology and Paediatric Infectious Diseases, University of Basel Children's Hospital, Basel, Switzerland.
¹⁷ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
¹⁸ Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium.
¹⁹ CIRI, Centre International de Recherche en Infectiologie, (Team VirPath), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France; Laboratoire de Virologie, Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69004, Lyon, France.
²⁰ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France. Electronic address: xavier.duval@aphp.fr.
²¹ RECOVER, REACTING, Santé Publique, France.
²² Agences régionales de santé.

PMID: 33545165
PMCID: PMC7857039
DOI: 10.1016/j.jinf.2021.01.026

Comment

High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Sarah Tubiana et al. J Infect. 2021 May.

. 2021 May;82(5):186-230.

doi: 10.1016/j.jinf.2021.01.026. Epub 2021 Feb 3.

Authors

Collaborators

Xavier Duval, Charles Burdet, Xavier Duval, Bruno Lina, Sarah Tubiana, Sylvie Van Der Werf, Fanny Abad, Dominique Abry, Loubna Alavoine, Jean-Sébastien Allain, Karline Amiel-Taieb, Pierre Audoin, Shana Augustin, Sandrine Ayala, Hélène Bansard, Fréderique Bertholon, Nolwenn Boissel, Elisabeth Botelho-Nevers, Kévin Bouiller, Marilou Bourgeon, Mathilde Boutrou, Lysiane Brick, Léa Bruneau, Eric Caumes, Agnès Chabouis, Eric Chan Thien, Catherine Chirouze, Bruno Coignard, Yolande Costa, Virginie Costenoble, Sylvie Cour, Claire Cracowski, Luc Cracowski Jean, Dominique Deplanque, Stéphane Dequand, Mireille Desille-Dugast, Maxime Desmarets, Maelle Detoc, Marie Dewitte, Felix Djossou, Jean-Luc Ecobichon, Elise Elrezzi, William Faurous, Viviane Fortuna, Julie Fouchard, Emilie Gantier, Céline Gautier, Patrick Gerardin, Sandrine Gerset, Marie Gilbert, Valérie Gissot, Francis Guillemin, Cédric Hartard, Béatrice Hazevis, Didier Hocquet, Enkelejda Hodaj, Emila Ilic-Habensus, Jeudy A, Helene Jeulin, Maty Kane, Emmanuelle Kasprzyk, John Kikoine, Fabrice Laine, Bruno Laviolle, David Lebeaux, Anne Leclercq, Eric Ledru, Benjamin Lefevre, Carole Legoas, Amélie Legrand, Karine Legrand, Jonathan Lehacaut, Claire Lehur, Dalila Lemouche, Quentin Lepiller, Sévérine Lepuil, Estelle Letienne, Aude Lucarelli, Jean-Christophe Lucet, Isabelle Madeline, Adrien Maillot, Catherine Malapate, Denis Malvy, Milica Mandic, Solène Marty-Quinternet, Mohamed Meghadecha, Mayka Mergeay-Fabre, Pauline Mespoulhe, Alexandre Meunier, Maria-Claire Migaud, Justina Motiejunaite, Gay Nathalie, Duc Nguyen, Soumaya Oubbea, Maïder Pagadoy, Adeline Paris, Christophe Paris, Christine Payet, Nathan Peiffer-Smadja, Lucas Perez, Pauline Perreau, Nathalie Pierrez, Thierry Pistone, Andreea Postolache, Patrick Rasoamanana, Cécile Reminiac, Jade Rexah, Elise Roche-Gouanvic, Alexandra Rousseau, Betty Schoemaecker, Sandrine Simon, Catherine Soler, Stéphanie Somers, Khaly Sow, Bernard Tardy, Zaven Terzian, Michael Thy, Anne Tournier, Sandrine Tyrode, Charline Vauchy, Renaud Verdon, Pauline Vernet, Valérie Vignali, Nawal Waucquier, Charles Burdet, Huong Do Thi Thu, Cédric Laouénan, France Mentre, Manchon Pauline, Sarah Tubiana, Aline Dechanet, Sophie Letrou, Caroline Quintin, Wahiba Frezouls, Quentin Le Hingrat, Nadhira Houhou, Florence Damond, Dianes Descamps, Charlotte Charpentier, Benoit Visseaux, Astrid Vabret, Bruno Lina, Maud Bouscambert, Sylvie Van Der Werf, Sylvie Behillil, Laurence Gaillanne, Nabil Benmalek, Mikael Attia, Marion Barbet, Caroline Demeret, Thierry Rose, Stéphane Petres, Nicolas Escriou, Marion Barbet, Stéphane Petres, Nicolas Escriou, Sophie Goyard, Ouifiya Kafif, Valentine Piquard, Sarah Tubiana, Bruno Coignard²¹, Alexandra Mailles²¹, Anne Simondon²², Marion Dreyere²², Bruno Morel²², Thiphaine Vesval²², Karine Amat, Douae Ammour, Khadija Aqourras, Sandrine Couffin-Cadiergues, Christelle Delmas, Vristi Desan, Michel Doute Jean, Hélène Esperou, Samia Hendou, Christelle Kouakam, Guillaume Le Meut, Soizic Lemestre, Nicolas Leturque, Emmanuelle Marcoul, Solange Nguefang, Layidé Roufai, Laurent Abel, Sophie Caillat-Zucman

Affiliations

¹ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Centre de Ressources Biologiques, F-75018 Paris, France.
² AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Département d'Epidémiologie, Biostatistique et Recherche, F-75018 Paris, France.
³ AP-HP, Hôpital Bichat, Laboratoire de Virologie, F-75018 Paris, France.
⁴ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France.
⁵ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; AP-HP, Hôpital Bichat, Département d'Epidémiologie, Biostatistique et Recherche, F-75018 Paris, France.
⁶ Université de Paris, IAME, INSERM, F-75018 Paris, France; Center for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS, INSERM, PSL Research University, Paris, France.
⁷ Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Laboratoire de Virologie, F-75018 Paris, France.
⁸ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France.
⁹ Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France; National Reference Center for Respiratory Viruses, Institut Pasteur, Paris, France.
¹⁰ AP-HP, Beaujon Hospital, Direction des soins, F-92118 Clichy, France.
¹¹ Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Equipe de Prévention du Risque Infectieux, F-75018 Paris, France.
¹² Université de Paris, IAME, INSERM, F-75018 Paris, France; AP-HP, Hôpital Bichat, Service de Maladies Infectieuses et tropicales, F-75018 Paris, France.
¹³ Physique des fonctions biologiques, CNRS UMR3738, Institut Pasteur, Paris, France.
¹⁴ Molecular Genetics of RNA Viruses, Department of Virology, CNRS UMR3569, Université de Paris, Institut Pasteur, Paris, France.
¹⁵ Biologie cellulaire des lymphocytes, INSERM - U1221, Department of Immunology, Institut Pasteur, Paris, France.
¹⁶ Paediatric Infectious Diseases Research Group, Institute for Infection and Immunity, St George's University of London, London SW17 0RE, United Kingdom; Paediatric Pharmacology and Paediatric Infectious Diseases, University of Basel Children's Hospital, Basel, Switzerland.
¹⁷ Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands.
¹⁸ Laboratory of Medical Microbiology, Vaccine and Infectious Disease Institute, Faculty of Medicine and Health Science, University of Antwerp, Antwerp, Belgium.
¹⁹ CIRI, Centre International de Recherche en Infectiologie, (Team VirPath), Univ Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, F-69007, Lyon, France; Laboratoire de Virologie, Centre National de Référence des Virus des infections respiratoires (dont la grippe), Institut des Agents Infectieux, Groupement Hospitalier Nord, Hospices Civils de Lyon, 69004, Lyon, France.
²⁰ AP-HP, Hôpital Bichat, Centre d'Investigation Clinique, Inserm CIC 1425, F-75018 Paris, France; Université de Paris, IAME, INSERM, F-75018 Paris, France. Electronic address: xavier.duval@aphp.fr.
²¹ RECOVER, REACTING, Santé Publique, France.
²² Agences régionales de santé.

PMID: 33545165
PMCID: PMC7857039
DOI: 10.1016/j.jinf.2021.01.026

No abstract available

Keywords: High-risk exposure; In-hospital workers; Personal protective equipment; Sars-cov-2; Transmission.

PubMed Disclaimer

Figures

**Fig. 1**
Proportions of symptomatic contact subjects among the 146 contacts of the CoV-CONTACT cohort. The orange curve corresponds to contacts subjects with confirmed SARS-CoV-2 infection (*i.e.*, virologically- or immunologically-proven, n = 35). The green curve corresponds to contacts subjects with possible SARS-CoV-2 infection (*i.e.*, clinically-suspected without viro-immunological confirmation, n = 28).

See this image and copyright information in PMC

Comment on

Clinical presentation of Covid-19 in health care workers from a French University Hospital.
Jary A, Flandre P, Chabouis A, Nguyen S, Marot S, Burrel S, Boutolleau D, Calvez V, Marcelin AG, Louet M. Jary A, et al. J Infect. 2020 Sep;81(3):e61-e63. doi: 10.1016/j.jinf.2020.06.048. Epub 2020 Jun 21. J Infect. 2020. PMID: 32579992 Free PMC article. No abstract available.
Snapshot PCR surveillance for SARS-CoV-2 in hospital staff in England.
Brown CS, Clare K, Chand M, Andrews J, Auckland C, Beshir S, Choudhry S, Davies K, Freeman J, Gallini A, Moores R, Patel T, Poznalska G, Rodger A, Roberts S, Rooney C, Wilcox M, Warren S, Ellis J, Gopal R, Dunning J, Zambon M, Hopkins S. Brown CS, et al. J Infect. 2020 Sep;81(3):427-434. doi: 10.1016/j.jinf.2020.06.069. Epub 2020 Jun 30. J Infect. 2020. PMID: 32615198 Free PMC article.

References

1. Brown C.S., Clare K., Chand M., Andrews J., Auckland C., Beshir S., et al. Snapshot PCR surveillance for SARS-CoV-2 in hospital staff in England. J Infect. Sep 2020;81(3):427–434. PubMed PMID:32615198. - PMC - PubMed
1. Jary A., Flandre P., Chabouis A., Nguyen S., Marot S., Burrel S., et al. Clinical presentation of Covid-19 in health care workers from a French University Hospital. J Infect. 2020 Sep;81(3):e61–e63. PubMed PMID: 32579992. - PMC - PubMed
1. Lescure F.X., Bouadma L., Nguyen D., Parisey M., Wicky P.H., Behillil S., et al. Clinical and virological data of the first cases of COVID-19 in Europe: a case series. Lancet Infect Dis. Jun 2020;20(6):697–706. PubMed PMID: 32224310. - PMC - PubMed
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High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

Collaborators

Affiliations

High-risk exposure without personal protective equipment and infection with SARS-CoV-2 in-hospital workers - The CoV-CONTACT cohort

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Collaborators

Affiliations

Figures

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References

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