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Case Reports
. 2021:27:100314.
doi: 10.1016/j.ctarc.2021.100314. Epub 2021 Jan 20.

Safety and efficacy of trastuzumab emtansine (TDM-1) in a patient on hemodialysis for renal failure

A Falcón González  1 , P Estévez Garcia  2 , A Sánchez Gastaldo  2 , I Sánchez Simón  2 , J Salvador Boffil  2 , M Ruiz Borrego  2
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Free article
Case Reports

Safety and efficacy of trastuzumab emtansine (TDM-1) in a patient on hemodialysis for renal failure

A Falcón González et al. Cancer Treat Res Commun. 2021.
Free article

Abstract

HER2-positive metastatic breast cancer is an aggressive disease with a limited number of treatment options. In the last 15 years, new drugs such as trastuzumab, pertuzumab, lapatinib or trastuzumab emtansine (TDM-1) have sprouted for these patients. There is a huge lack of evidence on the use of some of these drugs in patients with chronic renal failure, who need hemodialysis. We have reviewed the use of TDM-1 in these type of patients in the literature with unsuccessful results. In this article we want to present a case report to illustrate the safety and efficacy of TDM-1 in a patient on hemodialysis.

Keywords: Dialysis; Hemodialysis; Tdm-1; Trastuzumab emtansine.

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