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Multicenter Study
. 2021 Jan 22;100(3):e24000.
doi: 10.1097/MD.0000000000024000.

CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores in stroke with atrial fibrillation: A nationwide multicenter registry study

Inwu Yu  1 , Tae-Jin Song  2 , Bum Joon Kim  3 , Sung Hyuk Heo  4 , Jin-Man Jung  5 , Kyung-Mi Oh  6 , Chi Kyung Kim  6 , Sungwook Yu  7 , Kwang Yeol Park  8 , Jeong-Min Kim  9 , Jong-Ho Park  10 , Jay Chol Choi  11 , Man-Seok Park  12 , Joon-Tae Kim  12 , Yang-Ha Hwang  13 , Jong-Won Chung  1 , Oh Young Bang  1 , Geong-Moon Kim  1 , Yong-Jae Kim  14 , Seonwoo Kim  15 , Sook Young Woo  15 , Hyun Cho  15 , Woo-Keun Seo  1
Affiliations
Multicenter Study

CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores in stroke with atrial fibrillation: A nationwide multicenter registry study

Inwu Yu et al. Medicine (Baltimore). .

Abstract

The performance of scoring systems for risk stratification in patients with atrial fibrillation (AF) was not validated well in patients with stroke. The purpose of this study was to evaluate whether the risk scoring systems predict vascular outcomes in stroke patients with AF.Data were obtained from a nationwide multicenter registry for acute stroke with AF from January 1, 2013, to December 31, 2015. We investigated the predictive power of the CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke scores in stroke patients with AF. The subjects were further stratified into groups according to treatment with or without oral anticoagulants (OACs).A total of 3112 stroke with AF subjects were included. The rate of recurrent ischemic stroke and any stroke were not associated with the CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores. The risks of death and major adverse cerebrovascular and cardiovascular events (MACEs) increased sequentially with the increase of each risk score in OAC group. (the range of C-index 0.544-0.558 for recurrent ischemic stroke; 0.523-0.537 for any stroke; 0.580-0.597 for death; 0.564-0.583 for MACEs). However, in the group treated with OACs, all risk scores were significantly associated with the risk of MACEs. The C-statistics of the 4 scoring systems were 0.544 to 0.558, 0.523 to 0.537, 0.580 to 0.597, 0.564 to 0.583, respectively, for recurrent ischemic stroke, any stroke, death, and MACEs.The performance of the CHADS2, CHA2DS2-VASc, ATRIA, and Essen stroke risk scores for the prediction of recurrent stroke was unsatisfactory in stroke patients with AF whereas the performance for the prediction of recurrent stroke was not MACEs or death was good. A new risk stratification scheme that is specific for secondary stroke prevention in the AF population is needed.

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Conflict of interest statement

The other authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Forest plots for competing risk analysis showing hazard ratios of outcomes stratified by oral anticoagulant treatment history and risk scoring systems.
Figure 2
Figure 2
C-Statistics for the 4 scoring systems and vascular outcomes.
See this image and copyright information in PMC

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