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Meta-Analysis
. 2021 Jan 22;100(3):e24152.
doi: 10.1097/MD.0000000000024152.

Prognostic value of lymphocyte-to-monocyte ratio previously determined to surgery in patients with non-metastatic renal cell carcinoma: A systematic review and a prisma-compliant meta-analysis

Dario Garcia-Rojo  1 , Angel Prera  1 , Jesus Muñoz-Rodriguez  1 , Joan Carles Oliva  2 , Arturo Dominguez  1 , Joan Prats  1
Affiliations
Meta-Analysis

Prognostic value of lymphocyte-to-monocyte ratio previously determined to surgery in patients with non-metastatic renal cell carcinoma: A systematic review and a prisma-compliant meta-analysis

Dario Garcia-Rojo et al. Medicine (Baltimore). .

Abstract

Background: The prognostic value of pretreatment lymphocyte to monocyte ratio in patients with renal cell carcinoma and, especially, in non-metastatic patients remains controversial.

Methods: We conducted a PRISMA-compliant meta-analysis to systematically assess the prognostic value of LMR in patients with non-metastatic RCC. Overall survival, cancer-specific survival, and disease-free survival were analyzed. Pooled hazard ratios and 95% confidence intervals were calculated.

Results: Seven studies comprising 4666 patients were included in the analysis. Unlike those observed in a previous meta-analysis, a lower lymphocyte to monocyte ratio was associated with poorer cancer-specific survival (fix-effect model, hazard ratio 3.04, 95% confidence intervals 2.05-4.51, P < .05). Heterogeneity Chi-squared value Q exp = 0. (P = .82) (I2 = 0%). However, the association between a low lymphocyte to monocyte ratio and overall survival or disease-free survival did not obtain significance.

Conclusion: A lower lymphocyte to monocyte ratio implied poor cancer-specific survival in patients with non-metastatic renal cell carcinoma. Prospective studies are required to confirm our findings.

Registration number: ClinicalTrials.gov (identifier: NCT04213664).

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
PRISMA flow diagram of the systematic literature search. (PRISMA, preferred reporting items for systematic reviews and meta-analysis).
Figure 2
Figure 2
The forest plot of the relationship between the LMR and OS, CSS, and DFS in non-metastatic renal cell carcinoma. [CSS = cancer-specific survival, DFS = disease-free survival, LMR = lymphocyte-to-monocyte ratio, OS = overall survival].
Figure 3
Figure 3
The funnel plot of the Begg test for the publication bias assessment of the synthesized HR assessing the prognostic value of pretreatment LMR for CSS in non-metastatic renal cell cancer. [CSS = Cancer-specific survival, HR = Hazard ratio, LMR = lymphocyte-to-monocyte ratio].
See this image and copyright information in PMC

References

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