Toxicology and carcinogenesis studies of glycidamide in F344/N Nctr rats and B6C3F1/Nctr mice (drinking water studies)

Abstract

Glycidamide is a reactive electrophile that occurs primarily as a metabolite of acrylamide. Because acrylamide can be formed as a by-product during the cooking of starchy foods (including French fries, potato chips, and bread) and the roasting of coffee, the National Toxicology Program performed simultaneous studies to determine and compare the long-term effects of acrylamide and glycidamide in male and female F344/N Nctr rats and B6C3F1/Nctr mice. The data from the animals exposed to acrylamide formed the basis for NTP Technical Report 575. The results from the studies with glycidamide form the basis for the current report. (Abstract Abridged).