Basophils getting on your nerves? Itching for clarity on flares in atopic dermatitis

Affiliations

¹ Children's Hospital of Philadelphia, Division of Allergy Immunology and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Email: henricksons@email.chop.edu.

Comment

Sarah E Henrickson. Sci Immunol. 2021.

. 2021 Feb 5;6(56):eabg8047.

doi: 10.1126/sciimmunol.abg8047.

¹ Children's Hospital of Philadelphia, Division of Allergy Immunology and Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Email: henricksons@email.chop.edu.

Abstract

Flares of acute itch in the setting of atopic dermatitis may engage a novel neuroimmune axis that includes basophils, LTC4, and sensory neurons.

A basophil-neuronal axis promotes itch.
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