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Multicenter Study
. 2021 Jun;70(6):1061-1069.
doi: 10.1136/gutjnl-2020-323364. Epub 2021 Feb 5.

SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study

Sanjay Pandanaboyana  1   2 , John Moir  1 , John S Leeds  1   2 , Kofi Oppong  1   3 , Aditya Kanwar  4 , Ahmed Marzouk  5 , Ajay Belgaumkar  6 , Ajay Gupta  7 , Ajith K Siriwardena  8 , Ali Raza Haque  9 , Altaf Awan  10 , Anita Balakrishnan  11 , Arab Rawashdeh  12 , Bogdan Ivanov  13 , Chetan Parmar  14 , Christopher M Halloran  15 , Clifford Caruana  16 , Cynthia-Michelle Borg  17 , Dhanny Gomez  18 , Dimitrios Damaskos  19 , Dimitrios Karavias  20 , Guy Finch  21 , Husam Ebied  22 , James K Pine  23 , James R A Skipworth  24 , James Milburn  25 , Javed Latif  26 , Jeyakumar Ratnam Apollos  27 , Jihène El Kafsi  28 , John A Windsor  29 , Keith Roberts  30 , Kelvin Wang  31 , Krish Ravi  32 , Maria V Coats  33 , Marianne Hollyman  34 , Mary Phillips  35 , Michael Okocha  36 , Michael Sj Wilson  37 , Nadeem A Ameer  38 , Nagappan Kumar  39 , Nehal Shah  40 , Pierfrancesco Lapolla  41 , Connor Magee  42 , Bilal Al-Sarireh  43 , Raimundas Lunevicius  44 , Rami Benhmida  14 , Rishi Singhal  45 , Srinivasan Balachandra  46 , Semra Demirli Atıcı  47 , Shameen Jaunoo  48 , Simon Dwerryhouse  49 , Tamsin Boyce  50 , Vasileios Charalampakis  51 , Venkat Kanakala  52 , Zaigham Abbas  53 , Manu Nayar  54   3 ; COVID PAN collaborative group
Collaborators, Affiliations
Multicenter Study

SARS-CoV-2 infection in acute pancreatitis increases disease severity and 30-day mortality: COVID PAN collaborative study

Sanjay Pandanaboyana et al. Gut. 2021 Jun.

Abstract

Objective: There is emerging evidence that the pancreas may be a target organ of SARS-CoV-2 infection. This aim of this study was to investigate the outcome of patients with acute pancreatitis (AP) and coexistent SARS-CoV-2 infection.

Design: A prospective international multicentre cohort study including consecutive patients admitted with AP during the current pandemic was undertaken. Primary outcome measure was severity of AP. Secondary outcome measures were aetiology of AP, intensive care unit (ICU) admission, length of hospital stay, local complications, acute respiratory distress syndrome (ARDS), persistent organ failure and 30-day mortality. Multilevel logistic regression was used to compare the two groups.

Results: 1777 patients with AP were included during the study period from 1 March to 23 July 2020. 149 patients (8.3%) had concomitant SARS-CoV-2 infection. Overall, SARS-CoV-2-positive patients were older male patients and more likely to develop severe AP and ARDS (p<0.001). Unadjusted analysis showed that SARS-CoV-2-positive patients with AP were more likely to require ICU admission (OR 5.21, p<0.001), local complications (OR 2.91, p<0.001), persistent organ failure (OR 7.32, p<0.001), prolonged hospital stay (OR 1.89, p<0.001) and a higher 30-day mortality (OR 6.56, p<0.001). Adjusted analysis showed length of stay (OR 1.32, p<0.001), persistent organ failure (OR 2.77, p<0.003) and 30-day mortality (OR 2.41, p<0.04) were significantly higher in SARS-CoV-2 co-infection.

Conclusion: Patients with AP and coexistent SARS-CoV-2 infection are at increased risk of severe AP, worse clinical outcomes, prolonged length of hospital stay and high 30-day mortality.

Keywords: COVID-19; acute pancreatitis; pancreatitis.

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Conflict of interest statement

Competing interests: None declared.

Comment in

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