Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May;47(3):250-269.
doi: 10.1002/biof.1713. Epub 2021 Feb 6.

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

Seyede Atefe Hosseini  1   2 , Fatemeh Zahedipour  1   2 , Thozhukat Sathyapalan  3 , Tannaz Jamialahmadi  4   5 , Amirhossein Sahebkar  6   7   8   9
Affiliations
Review

Pulmonary fibrosis: Therapeutic and mechanistic insights into the role of phytochemicals

Seyede Atefe Hosseini et al. Biofactors. 2021 May.

Abstract

Pulmonary fibrosis (PF) is the devastating consequence of various inflammatory diseases of the lung. PF leads to a reduction of lung function, respiratory failure, and death. Several molecular pathways are involved in PF, such as inflammatory cytokines including tumor necrosis factor α (TNFα), tumor necrosis factor β1 (TNFβ1), interleukin 6 (IL-6), and interleukin 4 (IL-4), reactive oxygen species, matrix metalloproteases, and transforming growth factor-beta (TGF-β). Targeting these processes involved in the progression of PF is essential for the treatment of this disease. Natural products, including plant extracts and active compound that directly target the processes involved in PF, could be suitable therapeutic options with less adverse effects. In the present study, we reviewed the protective effects and the therapeutic role of various bioactive compounds from plants in PF management.

Keywords: curcumin; herbal medicine; lung; pulmonary fibrosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Wilson MS, Wynn TA. Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol. 2009;2:103-21.
    1. Chambers RC. Role of coagulation cascade proteases in lung repair and fibrosis. Eur Respir J Suppl. 2003;44:33s-5s.
    1. McKeown S, Richter AG, O'Kane C, McAuley DF, Thickett DR. MMP expression and abnormal lung permeability are important determinants of outcome in IPF. Eur Respir J. 2009;33:77-84.
    1. Hu Y, Peng J, Feng D, Chu L, Li X, Jin Z, et al. Role of extracellular signal-regulated kinase, p38 kinase, and activator protein-1 in transforming growth factor-beta1-induced alpha smooth muscle Actin expression in human fetal lung fibroblasts in vitro. Lung. 2006;184:33-42.
    1. Büttner C, Skupin A, Reimann T, Rieber EP, Unteregger G, Geyer P, et al. Local production of interleukin-4 during radiation-induced pneumonitis and pulmonary fibrosis in rats: macrophages as a prominent source of interleukin-4. Am J Respir Cell Mol Biol. 1997;17:315-25.

LinkOut - more resources