Age- and sex-related changes in the ratio between ankle and brachial systolic pressure in normal subjects

Abstract

The ratio between ankle (ASP) and brachial (BSP) systolic pressure was studied by using Doppler ultrasound in 198 normal subjects aged between twenty and ninety years: 97 males and 101 females. The ASP/BSP ratio decreased significantly with age both in males (r = -0.64; p less than 0.001) and in females (r = -0.72; p less than 0.001). In males, the decrease in the ratio with age was due to a significant decrease in ASP with age (r = -0.52; p less than 0.001), whereas BSP did not increase significantly with age. In females, a different result was observed, since only BSP (and not ASP) was significantly (and positively) correlated with age. In both sexes, the diameter of the terminal abdominal aorta measured by echocardiography was significantly increased with age, and full examination with Doppler ultrasound excluded any significant arterial stenosis of the lower limbs. The study provided evidence that age- and sex-related changes in arterial wave transmission do exist in normal subjects.