Whole exome sequencing of large populations: identification of loss of function alleles and implications for inherited kidney diseases

Affiliations

¹ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK; Renal Services, The Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
² Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK.
³ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK; Renal Services, The Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK. Electronic address: john.sayer@newcastle.ac.uk.

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Robert Geraghty et al. Kidney Int. 2021 Jun.

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. 2021 Jun;99(6):1255-1259.

doi: 10.1016/j.kint.2020.12.036. Epub 2021 Feb 5.

¹ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK; Renal Services, The Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
² Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK.
³ Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, International Centre for Life, Newcastle upon Tyne, UK; Renal Services, The Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne, UK. Electronic address: john.sayer@newcastle.ac.uk.

No abstract available

Keywords: chronic kidney disease; exome sequencing; gene expression.

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Exome sequencing and characterization of 49,960 individuals in the UK Biobank.
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