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Review
. 2021 Apr 5:525:111190.
doi: 10.1016/j.mce.2021.111190. Epub 2021 Feb 4.

Long non-coding RNAs in endometrial physiology and pathophysiology

Fatimah Aljubran  1 , Warren B Nothnick  2
Affiliations
Review

Long non-coding RNAs in endometrial physiology and pathophysiology

Fatimah Aljubran et al. Mol Cell Endocrinol. .

Abstract

The endometrium is an essential component of the female uterus which provides the environment for pregnancy establishment and maintenance. Abnormalities of the endometrium not only lead to difficulties in establishing and maintaining pregnancy but also play a causative role in diseases of endometrial origin including endometriosis and endometrial cancer. Non-coding RNAs are proposed to play a role in regulating the genome in both normal endometrial physiology and pathophysiology. In this review, we first provide a general overview of non-coding RNAs and reproductive physiology of the endometrium. We then discuss the role on non-coding RNAs in normal endometrial physiology and pathophysiology of endometrial infertility. We then conclude with non-coding RNAs in the pathophysiology of endometriosis and endometrial cancer.

Keywords: Endometrial cancer; Endometriosis; Endometrium; Infertility; Non-coding RNAs; Preeclampsia; Pregnancy.

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