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1 Department of Intensive Care Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com), the Netherlands. Electronic address: j.smit6@amsterdamumc.nl.
2 Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com), the Netherlands.
3 Department of Intensive Care Medicine, Tergooi Hospital, Hilversum, the Netherlands.
4 Department of Intensive Care Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
5 Department of Intensive Care Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
6 Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
7 Department of Intensive Care Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com), the Netherlands.
1 Department of Intensive Care Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com), the Netherlands. Electronic address: j.smit6@amsterdamumc.nl.
2 Department of Intensive Care Medicine, Leiden University Medical Center, Leiden, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com), the Netherlands.
3 Department of Intensive Care Medicine, Tergooi Hospital, Hilversum, the Netherlands.
4 Department of Intensive Care Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
5 Department of Intensive Care Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands.
6 Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
7 Department of Intensive Care Medicine, Amsterdam University Medical Centers, VU University, Amsterdam, the Netherlands; Amsterdam Cardiovascular Sciences Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands; Amsterdam Leiden Intensive care Focused Echography (ALIFE, www.alifeofpocus.com), the Netherlands.
All authors declare to have no conflicts of interest.
Figures
Fig. 1
Forest plots of baseline characteristics…
Fig. 1
Forest plots of baseline characteristics (1a), univariate and multivariate analysis of primary outcome…
Fig. 1
Forest plots of baseline characteristics (1a), univariate and multivariate analysis of primary outcome (1b and 1c). Crude and adjusted odds ratios are shown with their respective 95% confidence interval. Continuous variables are shown as per ‘one’ increase unless specified otherwise. Model likelihood-ratio test: Χ2 = 34.65, df = 5, p < 0.0001; Nagelkerke R2 = 0.53. a: time until ultrasound examination. b: data only applicable to or available from COVID-19 patients. c: at time of CVC insertion. APTT: activated partial thromboplastin time; BMI: body mass index; CI: confidence interval; COVID-19: coronavirus disease 2019; CRP: C-reactive protein; CRT: catheter-related thrombosis; CVC: central venous catheter; Double: double prophylactic; FV: femoral vein; ICU: intensive care unit; IJV: internal jugular vein; INR: international normalized ratio; OR: odds ratio; PT: prothrombin time; Ref: reference; SD: standard deviation; SOFA: sequential organ failure assessment; Standard: standard prophylactic; WBC: white blood cell count.
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