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Observational Study
. 2021 Mar:84:40-46.
doi: 10.1016/j.parkreldis.2021.01.018. Epub 2021 Jan 29.

Skin conditions in early Parkinson's disease

Deepika Dinesh  1 , Jong Soo Lee  2 , Xiang Gao  3 , Natalia Palacios  4
Affiliations
Observational Study

Skin conditions in early Parkinson's disease

Deepika Dinesh et al. Parkinsonism Relat Disord. 2021 Mar.

Abstract

Objective: Skin conditions have been associated with increased risk of Parkinson's disease (PD). Little is known about clinical and biomarker differences according to presence of skin conditions among PD patients. Studying these differences might provide insight into PD pathogenesis.

Methods: We examined the association between common skin conditions and risk of PD in a case-control study of 423 early drug-naïve PD cases and 196 healthy controls (HC) in the Parkinson's Progression Markers Initiative (PPMI). Among PD participants, we examined if skin conditions were associated with clinical and PD-relevant biomarkers.

Results: Skin conditions occurred more frequently among PD participants (41%) relative to HC (32%). In multivariate analyses, we observed an association between any skin condition and PD (OR = 1.49, 95% CI = 1.03-2.16) and basal cell carcinoma and PD (OR = 2.05, 95% CI = 1.02-4.08). PD participants who reported skin conditions were older (OR = 1.68, 95% CI = 1.21-2.35) more educated (OR = 1.70, 95% CI = 0.99-2.91), had higher Semantic Fluency Test (SFT) scores (OR = 1.45, 95% CI = 1.07-1.96) and Hopkins Verbal Learning Test (HVLT) retention scores (OR = 1.55, 95% CI = 1.09-2.22) compared to PD patients without skin conditions. None of the associations remained significant after Bonferroni correction for multiple comparisons.

Conclusions: We observed a positive association between any skin condition as well as basal cell carcinoma and PD. PD participants with skin conditions were older, more educated, had higher SFT and HVLT retention scores compared to those without skin conditions. However, all associations were no longer significant after Bonferroni multiple comparisons correction. Observed associations should be confirmed in larger, longitudinal studies.

Keywords: Parkinson's disease; Skin conditions.

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Figures

Fig. 1.
Fig. 1.
Association between any skin condition and predictors among PD participants.
See this image and copyright information in PMC

References

    1. Ascherio A, Schwarzschild MA, The epidemiology of Parkinson’s disease: risk factors and prevention, Lancet Neurol. 15 (12) (2016) 1257–1272. - PubMed
    1. Storelli E, Cassina N, Rasini E, Marino F, Cosentino M, Do Th17 lymphocytes and IL-17 contribute to Parkinson’s disease? A systematic review of available evidence, Front. Neurol. 10 (2019. Jan 24) 13. - PMC - PubMed
    1. Houlden H, Singleton AB, The genetics and neuropathology of Parkinson’s disease, Acta Neuropathol. 124 (3) (2012) 325–338. - PMC - PubMed
    1. Heilbron K, Noyce AJ, Fontanillas P, Alipanahi B, Nalls MA, Cannon P, The Parkinson’s phenome-traits associated with Parkinson’s disease in a broadly phenotyped cohort, NPJ Parkinson’s Disease 5 (2019) 4, 4. - PMC - PubMed
    1. Weintraub D, Simuni T, Caspell-Garcia C, Coffey C, Lasch S, Siderowf A, Aarsland D, Barone P, Burn D, Chahine LM, Eberling J, Espay AJ, Foster ED, Leverenz JB, Litvan I, Richard I, Troyer MD, Hawkins KA, Cognitive performance and neuropsychiatric symptoms in early, untreated Parkinson’s disease, Mov. Disord. (7) (2015) 919. - PMC - PubMed

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