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. 2021 May;33(5):e14092.
doi: 10.1111/nmo.14092. Epub 2021 Feb 7.

Impact of COVID-19 lockdown on symptoms in patients with functional gastrointestinal disorders: Relationship with anxiety and perceived stress

Giovanni Oliviero  1 , Luigi Ruggiero  1 , Elvira D'Antonio  1 , Mario Gagliardi  1 , Rubino Nunziata  1 , Alessandro Di Sarno  1 , Carmelina Abbatiello  1 , Elvira Di Feo  1 , Simona De Vivo  1 , Antonella Santonicola  1 , Paola Iovino  1
Affiliations

Impact of COVID-19 lockdown on symptoms in patients with functional gastrointestinal disorders: Relationship with anxiety and perceived stress

Giovanni Oliviero et al. Neurogastroenterol Motil. 2021 May.

Abstract

Background: Psychological stress and anxiety, such those generated by forced quarantine, affect gastrointestinal symptoms course in patients with functional gastrointestinal disorders. Thus, our aim was to assess, in a cohort of patients regularly followed up in a devoted outpatient clinic of Southern Italy, the association between their gastrointestinal symptoms changes, stress, and anxiety reported during the Italian lockdown.

Methods: We recruited patients from the outpatient clinic of the University of Salerno, devoted to functional gastrointestinal disorders, selecting only patients for whom an evaluation was available in the last 6 months before the lockdown. Gastrointestinal symptoms were evaluated at each visit through standardized questionnaire and pooled in a database. On 45th days from the beginning of the lockdown, patients were re-assessed by phone with the same questionnaire. Anxiety and stress levels were assessed through a self-administered online questionnaire based on Generalized Anxiety Disorder 7 test and Perceived Stress Scale 10 test.

Key results: The intensity-frequency scores of several upper gastrointestinal symptoms improved (Wilcoxon test <0.05). Higher anxiety levels had a higher risk of worsening chest pain (OR 1.3 [1.1-1.7]), waterbrash (OR 1.3 [1.0-1.7]), epigastric burning (OR 1.3 [1.0-1.6]), and abdominal pain (OR 1.6 [1.0-2.3]). When compared to the interval preceding the outbreak, half of the patients declared their symptoms remained unchanged, 13.6% worsened, and 36.4% improved.

Conclusions and inferences: During the COVID-19 quarantine, there was an improvement of the majority of upper gastrointestinal symptoms in our patients, and anxiety seems an important risk of worsening few of them.

Keywords: anxiety; covid-19; gastrointestinal diseases; quarantine; stress.

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Conflict of interest statement

The authors have no conflicts of interest to disclose. This article is not submitted or under consideration by any other publication.

Figures

FIGURE 1
FIGURE 1
Box plots of upper and lower GI symptoms before (□) and during late COVID‐19 lockdown (■)
FIGURE 2
FIGURE 2
Percentage of patients who considered themselves improved, unchanged, and worsened compared to the interval preceding the COVID‐19 outbreak classified as functional heartburn (FH), functional dyspepsia (FD), and irritable bowel syndrome (IBS)
See this image and copyright information in PMC

Comment in

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