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Case Reports
. 2021 Jul 1;60(13):2075-2079.
doi: 10.2169/internalmedicine.6303-20. Epub 2021 Feb 8.

Inflammatory Pseudo-tumor of the Liver Accompanied by Eosinophilia

Yoshihide Matsumoto  1 , Kento Ogawa  1 , Akiko Shimizu  1 , Masaharu Nakamura  1 , Shinya Hoki  1 , Shigenobu Kuroki  1 , Yasumichi Yano  1 , Kozo Ikuta  1 , Eri Senda  1 , Seiji Shio  1
Affiliations
Case Reports

Inflammatory Pseudo-tumor of the Liver Accompanied by Eosinophilia

Yoshihide Matsumoto et al. Intern Med. .

Abstract

A 28-year-old woman was referred to our hospital for liver dysfunction and neck pain. Blood tests revealed elevated liver enzymes and eosinophilia. Ultrasonography, computed tomography, and magnetic resonance imaging showed a mass lesion near the hepatic hilus. The tumor was considered to be an inflammatory pseudo-tumor or malignancy. A liver-mass biopsy was performed and led to a diagnosis of inflammatory pseudo-tumor. In the present case, a markedly elevated eosinophil count was a characteristic clinical feature, and the patient underwent steroid therapy. Treatment resulted in a reduced eosinophil count, improved neck symptoms, and disappearance of the inflammatory pseudo-tumor.

Keywords: eosinophilia; inflammatory pseudo-tumor; liver dysfunction.

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Conflict of interest statement

The authors state that they have no Conflict of Interest (COI).

Figures

Figure 1.
Figure 1.
Abdominal ultrasonography (US) image showing a low-echoic mass lesion (arrow) (A), sonazoid-enhanced US image showing a high-echoic mass lesion at the early vascular phase (B), and sonazoid-enhanced US image showing a hypoechoic mass lesion at the post-vascular phase (C).
Figure 2.
Figure 2.
Computed tomography (CT) image of the abdomen showing a mass located near the porta hepatis (arrow) in the plain image (A), the arterial phase (B), and the equilibrium phase (C).
Figure 3.
Figure 3.
Abdominal magnetic resonance imaging (MRI) showing a mild hypointense mass (arrow) on T1-weighted imaging (A), a slightly higher-signal-intensity mass on T2-weighted imaging (B), a mass with rim-like enhancement on dynamic gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced MRI (EOB-MRI) (early phase) (C), and a hyperintense mass with an internal hypointense area on dynamic EOB-MRI (hepatobiliary phase) (D).
Figure 4.
Figure 4.
Hematoxylin and Eosin staining showing the presence of inflammatory cell infiltration (A, low-power field; B, high-power field). Immunohistochemistry showing alpha-SMA (C), IgG (D), and IgG4 (E).
See this image and copyright information in PMC

References

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