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Review
. 2021 Jan 20:11:583191.
doi: 10.3389/fphys.2020.583191. eCollection 2020.

Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?

Francisco Santos  1 , Magda Correia  1 , Sandrina Nóbrega-Pereira  1   2 , Bruno Bernardes de Jesus  1
Affiliations
Review

Age-Related Pathways in Cardiac Regeneration: A Role for lncRNAs?

Francisco Santos et al. Front Physiol. .

Abstract

Aging imposes a barrier for tissue regeneration. In the heart, aging leads to a severe rearrangement of the cardiac structure and function and to a subsequent increased risk of heart failure. An intricate network of distinct pathways contributes to age-related alterations during healthy heart aging and account for a higher susceptibility of heart disease. Our understanding of the systemic aging process has already led to the design of anti-aging strategies or to the adoption of protective interventions. Nevertheless, our understanding of the molecular determinants operating during cardiac aging or repair remains limited. Here, we will summarize the molecular and physiological alterations that occur during aging of the heart, highlighting the potential role for long non-coding RNAs (lncRNAs) as novel and valuable targets in cardiac regeneration/repair.

Keywords: heart; lncRNAs; regeneration; reprogramming; transdifferentiation.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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