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Case Reports
. 2021 Jan 26;11(1):89-93.
doi: 10.1080/20009666.2020.1836726.

Acquired Hemophilia A and urothelial carcinoma

Fadi Taza  1 , Nawar Suleman  1 , Robert Paz  2 , Christopher Haas  1   3
Affiliations
Case Reports

Acquired Hemophilia A and urothelial carcinoma

Fadi Taza et al. J Community Hosp Intern Med Perspect. .

Abstract

Acquired Hemophilia A (AHA) is a rare entity, resulting from the production of autoantibodies against Factor VIII of the coagulation cascade. These autoantibodies may develop in response to autoimmune conditions, drugs, neoplastic diseases, and pregnancy. Diagnosis involves clinical presentation, mucocutaneous or intramuscular bleeding, and laboratory findings, such as prolonged activated partial thromboplastin time, decreased levels of Factor VIII, and the presence of Factor VIII autoantibodies. The etiology is diverse, with a variety of underlying culprits. Malignancy-associated AHA has been associated with approximately 15% of cases. Urothelial malignancy-mediated AHA is exceedingly rare, with only two previously published reports. The management of AHA includes stabilization and control of bleeding via the use of hemostatic agents, and elimination of the inhibitor with immunosuppressive therapy. Here, we report a case of AHA secondary to urothelial malignancy and review the pathobiology and pathogenesis of Hemophilia A and AHA.

Keywords: Acquired Hemophilia; Urothelial carcinoma; blood disorder; malignancy.

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Conflict of interest statement

No potential conflict of interest was reported by the authors.

Figures

Figure 1.
Figure 1.
Computed Tomography of the lower extremities demonstrates a large intramuscular hematoma in the posterior right thigh
See this image and copyright information in PMC

References

    1. Green D, Lechner K.. A survey of 215 non-hemophilic patients with inhibitors to factor VIII. Thromb Haemost. 1981;45(3):200–203. - PubMed
    1. Collins PW, Hirsch S, Baglin TP, et al. Acquired hemophilia A in the UK: a 2-year national surveillance study by the UK Haemophilia centre doctors’ organisation. Blood. 2007;109(5):1870–1877. - PubMed
    1. Knoebl P, Marco P, Baudo F, et al. Demographic and clinical data in acquired hemophilia A: results from the European Acquired Haemophilia Registry (EACH2). J Thromb Haemost. 2012;10(4):622–631.. - PubMed
    1. Reeves BN, Key NS. Acquired hemophilia in malignancy. Thromb Res. 2012;129(Suppl):S66–8. - PubMed
    1. Cohen AJ, Kessler CM. Acquired inhibitors. Baillieres Clin Haematol. 1996;9(2):331–354. - PubMed

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