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Review
. 2021 Jan 12;7(3):FSO643.
doi: 10.2144/fsoa-2020-0154.

Clinical factors affecting prostate-specific antigen levels in prostate cancer patients undergoing radical prostatectomy: a retrospective study

Giovanni Tarantino  1 , Felice Crocetto  2 , Concetta Di Vito  2 , Raffaele Martino  2 , Savio Domenico Pandolfo  2 , Massimiliano Creta  2 , Achille Aveta  2 , Carlo Buonerba  3 , Ciro Imbimbo  2
Affiliations
Review

Clinical factors affecting prostate-specific antigen levels in prostate cancer patients undergoing radical prostatectomy: a retrospective study

Giovanni Tarantino et al. Future Sci OA. .

Abstract

Background: Since prostate-specific antigen (PSA) levels can be influenced by some routinely available clinical factors, a retrospective study was conducted to explore the influence of obesity, smoking habit, heavy drinking and chronic obstructive pulmonary disease on PSA levels in men with histologically confirmed prostate cancer.

Patients & methods: We reviewed the medical records of 833 prostate cancer patients undergoing radical prostatectomy.

Results: Serum PSA levels at the time of surgery were not associated with either BMI or history of chronic obstructive pulmonary disease or heavy drinking. Conversely, PSA levels were associated with smoking status.

Conclusion: Among the clinical factors explored in this homogeneous population, only tobacco use was associated with PSA levels, which should be considered when using PSA-based screening in male smokers.

Keywords: BMI; COPD; Gleason score; heavy drinking; smoking habit; total PSA.

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Conflict of interest statement

Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

Figure 1.
Figure 1.. Distribution of total prostate-specific antigen levels according to BMI.
The flat regression line indicates no statistical significance. PSA: Prostate-specific antigen.
See this image and copyright information in PMC

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