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. 2021 Jan 22:2021:6667779.
doi: 10.1155/2021/6667779. eCollection 2021.

Dosimetry and Comparison between Different CT Protocols (Low Dose, Ultralow Dose, and Conventional CT) for Lung Nodules' Detection in a Phantom

Cleverson Alex Leitão  1 , Gabriel Lucca de Oliveira Salvador  1 , Priscilla Tazoniero  1 , Danny Warszawiak  1 , Cristian Saievicz  1 , Rosangela Requi Jakubiak  2 , Dante Luiz Escuissato  1
Affiliations

Dosimetry and Comparison between Different CT Protocols (Low Dose, Ultralow Dose, and Conventional CT) for Lung Nodules' Detection in a Phantom

Cleverson Alex Leitão et al. Radiol Res Pract. .

Abstract

Background: The effects of dose reduction in lung nodule detection need better understanding.

Purpose: To compare the detection rate of simulated lung nodules in a chest phantom using different computed tomography protocols, low dose (LD), ultralow dose (ULD), and conventional (CCT), and to quantify their respective amount of radiation.

Materials and methods: A chest phantom containing 93 simulated lung nodules was scanned using five different protocols: ULD (80 kVp/30 mA), LD A (120 kVp/20 mA), LD B (100 kVp/30 mA), LD C (120 kVp/30 mA), and CCT (120 kVp/automatic mA). Four chest radiologists analyzed a selected image from each protocol and registered in diagrams the nodules they detected. Kruskal-Wallis and McNemar's tests were performed to determine the difference in nodule detection. Equivalent doses were estimated by placing thermoluminescent dosimeters on the surface and inside the phantom.

Results: There was no significant difference in lung nodules' detection when comparing ULD and LD protocols (p=0.208 to p=1.000), but there was a significant difference when comparing each one of those against CCT (p < 0.001). The detection rate of nodules with CT attenuation values lower than -600 HU was also different when comparing all protocols against CCT (p < 0.001 to p=0.007). There was at least moderate agreement between observers in all protocols (κ-value >0.41). Equivalent dose values ranged from 0.5 to 9 mSv.

Conclusion: There is no significant difference in simulated lung nodules' detection when comparing ULD and LD protocols, but both differ from CCT, especially when considering lower-attenuating nodules.

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Conflict of interest statement

All authors declare that there are no conflicts of interest.

Figures

Figure 1
Figure 1
Example of the selected CT slice the radiologists analyzed and the printed diagram in which they registered the nodules they detected. Peripheral nodules such as A3, A4, and B2 were excluded from analysis because of their interface with the chest wall. Positions E2, E11, and F9 had no simulated nodules and served as reference to count columns and rows.
Figure 2
Figure 2
The number of nodules detected (gray columns, number 1) and missed (black columns, number 0) in each protocol (numbers 1 to 5, lower row) for every radiologist (numbers 1 to 4, upper row). Protocol 1: ULD, protocol 2: LD A, protocol 3: LD B, protocol 4: LD C, and protocol 5: CCT.
See this image and copyright information in PMC

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