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Review
. 2021 Jan 22:2021:8816041.
doi: 10.1155/2021/8816041. eCollection 2021.

Th17 Cells in Inflammatory Bowel Disease: Cytokines, Plasticity, and Therapies

Junjun Zhao  1   2 , Qiliang Lu  3 , Yang Liu  3 , Zhan Shi  4 , Linjun Hu  3 , Zhi Zeng  3 , Yifeng Tu  4 , Zunqiang Xiao  4 , Qiuran Xu  2
Affiliations
Review

Th17 Cells in Inflammatory Bowel Disease: Cytokines, Plasticity, and Therapies

Junjun Zhao et al. J Immunol Res. .

Abstract

Autoimmune diseases (such as rheumatoid arthritis, asthma, autoimmune bowel disease) are a complex disease. Improper activation of the immune system or imbalance of immune cells can cause the immune system to transform into a proinflammatory state, leading to autoimmune pathological damage. Recent studies have shown that autoimmune diseases are closely related to CD4+ T helper cells (Th). The original CD4 T cells will differentiate into different T helper (Th) subgroups after activation. According to their cytokines, the types of Th cells are different to produce lineage-specific cytokines, which play a role in autoimmune homeostasis. When Th differentiation and its cytokines are not regulated, it will induce autoimmune inflammation. Autoimmune bowel disease (IBD) is an autoimmune disease of unknown cause. Current research shows that its pathogenesis is closely related to Th17 cells. This article reviews the role and plasticity of the upstream and downstream cytokines and signaling pathways of Th17 cells in the occurrence and development of autoimmune bowel disease and summarizes the new progress of IBD immunotherapy.

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Conflict of interest statement

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1
Figure 1
Differentiation of Th17 cell.
Figure 2
Figure 2
Functions of Th17 cell.
See this image and copyright information in PMC

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