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. 1988 Apr;45(4):435-7.
doi: 10.1001/archneur.1988.00520280085020.

Fatigue in multiple sclerosis

L B Krupp  1 , L A Alvarez, N G LaRocca, L C Scheinberg
Affiliations

Fatigue in multiple sclerosis

L B Krupp et al. Arch Neurol. 1988 Apr.

Abstract

Fatigue is a frequent symptom in multiple sclerosis (MS) that can interfere with a patient's daily functioning. The cause of MS fatigue, its clinical characteristics, and its relationship to other symptoms remain poorly understood. Structured interviews were conducted with 32 patients with MS and 33 normal healthy adults. Fatigue proved to be both more frequent and more severe among the patients with MS. Multiple sclerosis fatigue was unrelated to either depression or global impairment. Multiple sclerosis fatigue appears to be a distinct clinical entity, often disabling, that can be distinguished from normal fatigue, affective disturbance, and neurologic impairment.

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Comment in

  • Fatigue in multiple sclerosis.
    Rosse RB. Rosse RB. Arch Neurol. 1989 Aug;46(8):841-2. doi: 10.1001/archneur.1989.00520440021010. Arch Neurol. 1989. PMID: 2787980 No abstract available.

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