Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec;58(4):254-267.
doi: 10.5152/tao.2020.5218. Epub 2020 Dec 1.

Photodynamic Therapy as a New Treatment for Chronic Rhinosinusitis - A Systematic Review

Anika Kaura  1 , Rishi Shukla  2 , Abigail Lamyman  2 , Robert Almeyda  3 , Mark Draper  4 , Pablo Martinez-Devesa  2 , Ali Qureishi  2
Affiliations
Review

Photodynamic Therapy as a New Treatment for Chronic Rhinosinusitis - A Systematic Review

Anika Kaura et al. Turk Arch Otorhinolaryngol. 2020 Dec.

Abstract

This review examines the latest evidence for photodynamic therapy (PDT) in treating chronic rhinosinusitis. MedLine, EMBASE and TRIP Database searches were conducted using the terms: "photodynamic" or "phototherapy" or "photo" and "sinusitis" or "rhinosinusitis," date range January 2000 to May 2020. A total of 192 records were initially identified, after duplicates and exclusions, 9 full papers and 3 abstracts were included. All study types including in-vitro, animal and human studies were evaluated. Whilst there is in-vitro evidence for the efficacy of PDT's bactericidal effect on drug resistant bacteria and biofilm viability, there are few clinical studies. PDT is a promising area of research, but larger, focused studies looking at the safety, delivery, efficacy, and patient selection are required before it can be considered a viable treatment for CRS.

Keywords: Phototherapy; alternative therapies; paranasal sinus diseases; photodynamic therapy; sinusitis.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Classification of Primary and Secondary Chronic Rhinosinusitis (adapted from Grayson et al. [2])
Figure 2
Figure 2
PRISMA Flow Diagram for Systematic Review
See this image and copyright information in PMC

References

    1. Dietz de Loos D, Lourijsen ES, Wildeman MAM, Freling NJM, Wolvers MDJ, Reitsma S, et al. Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology. J Allergy Clin Immunol. 2019;143:1207–14. doi: 10.1016/j.jaci.2018.12.986. - DOI - PubMed
    1. Grayson JW, Hopkins C, Mori E, Senior B, Harvey RJ. Contemporary Classification of Chronic Rhinosinusitis Beyond Polyps vs No Polyps: A Review. JAMA Otolaryngol Head Neck Surg. 2020 doi: 10.1001/jamaoto.2020.1453. - DOI - PubMed
    1. Philpott CM, Erskine S, Hopkins C, Kumar N, Anari S, Kara N, et al. Prevalence of asthma, aspirin sensitivity and allergy in chronic rhinosinusitis: data from the UK National Chronic Rhinosinusitis Epidemiology Study. Respir Res. 2018;19:129. doi: 10.1186/s12931-018-0823-y. - DOI - PMC - PubMed
    1. Jarvis D, Newson R, Lotvall J, Hastan D, Tomassen P, Keil T, et al. Asthma in adults and its association with chronic rhinosinusitis: the GA2LEN survey in Europe. Allergy. 2012;67:91–8. doi: 10.1111/j.1398-9995.2011.02709.x. - DOI - PubMed
    1. Gudis D, Zhao KQ, Cohen NA. Acquired cilia dysfunction in chronic rhinosinusitis. Am J Rhinol Allergy. 2012;26:1–6. doi: 10.2500/ajra.2012.26.3716. - DOI - PMC - PubMed

LinkOut - more resources