Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jun;113(6):272-280.
doi: 10.1111/boc.202000135. Epub 2021 Feb 26.

The NANOTUMOR consortium - Towards the Tumor Cell Atlas

Florent Colin  1 , Kristine Schauer  2 , Ali Hamiche  3 , Pierre Martineau  4 , Jean-Paul Borg  5   6 , Jan Bednar  7 , Giulia Bertolin  8 , Luc Camoin  5 , Yves Collette  5 , Stephan Dimitrov  7 , Isabelle Fournier  6   9 , Vincent Hyenne  1 , Marco A Mendoza-Parra  10 , Xavier Morelli  5 , Philippe Rondé  11   12 , Izabela Sumara  3 , Marc Tramier  8 , Patrick Schultz  3 , Jacky G Goetz  1
Affiliations
Free article
Review

The NANOTUMOR consortium - Towards the Tumor Cell Atlas

Florent Colin et al. Biol Cell. 2021 Jun.
Free article

Abstract

Cancer is a multi-step disease where an initial tumour progresses through critical steps shaping, in most cases, life-threatening secondary foci called metastases. The oncogenic cascade involves genetic, epigenetic, signalling pathways, intracellular trafficking and/or metabolic alterations within cancer cells. In addition, pre-malignant and malignant cells orchestrate complex and dynamic interactions with non-malignant cells and acellular matricial components or secreted factors within the tumour microenvironment that is instrumental in the progression of the disease. As our aptitude to effectively treat cancer mostly depends on our ability to decipher, properly diagnose and impede cancer progression and metastasis formation, full characterisation of molecular complexes and cellular processes at play along the metastasis cascade is crucial. For many years, the scientific community lacked adapted imaging and molecular technologies to accurately dissect, at the highest resolution possible, tumour and stromal cells behaviour within their natural microenvironment. In that context, the NANOTUMOR consortium is a French national multi-disciplinary workforce which aims at a providing a multi-scale characterisation of the oncogenic cascade, from the atomic level to the dynamic organisation of the cell in response to genetic mutations, environmental changes or epigenetic modifications. Ultimately, this program aims at identifying new therapeutic targets using innovative drug design.

Keywords: Cancer; Cellular Imaging; Electron & Light Microscopy; Metastasis; Oncology.

PubMed Disclaimer

References

    1. Bertolin, G., Sizaire, F., Herbomel, G., Reboutier, D., Prigent, C., & Tramier, M. (2016). A FRET biosensor reveals spatiotemporal activation and functions of aurora kinase A in living cells. Nat. Commun., 7(1), 12674. https://doi.org/10.1038/ncomms12674
    1. Branon, T. C., Bosch, J. A., Sanchez, A. D., Udeshi, N. D., Svinkina, T., Carr, S. A., Feldman, J. L., Perrimon, N., & Ting, A. Y. (2018). Efficient proximity labeling in living cells and organisms with TurboID. Nat. Biotechnol., 36(9), 880-887. https://doi.org/10.1038/nbt.4201
    1. Charafe-Jauffret, E., Ginestier, C., Bertucci, F., Cabaud, O., Wicinski, J., Finetti, P., Josselin, E., Adelaide, J., Nguyen, T. T., Monville, F., Jacquemier, J., Thomassin-Piana, J., Pinna, G., Jalaguier, A., Lambaudie, E., Houvenaeghel, G., Xerri, L., Harel-Bellan, A., Chaffanet, M., … Birnbaum, D. (2013). ALDH1-positive cancer stem cells predict engraftment of primary breast tumors and are governed by a common stem cell program. Cancer Res., 73(24), 7290-7300. https://doi.org/10.1158/0008-5472.CAN-12-4704
    1. Geladaki, A., Kočevar Britovšek, N., Breckels, L. M., Smith, T. S., Vennard, O. L., Mulvey, C. M., Crook, O. M., Gatto, L., & Lilley, K. S. (2019). Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics. Nat. Commun., 10(1), 331. https://doi.org/10.1038/s41467-018-08191-w
    1. Gensbittel, V., Kräter, M., Harlepp, S., Busnelli, I., Guck, J., & Goetz, J. G. (2020). Mechanical adaptability of tumor cells in metastasis. Dev. Cell, 2020, 1-16. https://doi.org/10.1016/j.devcel.2020.10.011