Biological variation of serum insulin: updated estimates from the European Biological Variation Study (EuBIVAS) and meta-analysis

Anna Carobene¹, Elisabet Gonzalez Lao², Margarida Simon³, Massimo Locatelli¹, Abdurrahman Coşkun⁴, Jorge Díaz-Garzón^{5

6}, Pilar Fernandez-Calle^{5

6}, Sverre Sandberg^{7

8

9}, Aasne K Aarsand^{7

8}

Affiliations

¹ Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
² Quality Healthcare Consulting, Grupo ACMS, Madrid, Spain.
³ Intercomarcal Laboratory Consortium of l'Alt Penedés, l'Anoia i el Garraf, Barcelona, Spain.
⁴ School of Medicine, Acibadem Mehmet Ali Aydınlar University, Istanbul, Turkey.
⁵ Hospital Universitario La Paz, Madrid, Spain.
⁶ Quality Analytical Commission of Spanish Society of Clinical Chemistry (SEQC), Barcelona, Spain.
⁷ Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
⁸ Norwegian Organization for Quality Improvement of Laboratory Examinations (Noklus), Bergen, Norway.
⁹ Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

Free article

Anna Carobene et al. Clin Chem Lab Med. 2020.

Free article

. 2020 Nov 25;60(4):518-522.

doi: 10.1515/cclm-2020-1490. Print 2022 Mar 28.

¹ Laboratory Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
² Quality Healthcare Consulting, Grupo ACMS, Madrid, Spain.
³ Intercomarcal Laboratory Consortium of l'Alt Penedés, l'Anoia i el Garraf, Barcelona, Spain.
⁴ School of Medicine, Acibadem Mehmet Ali Aydınlar University, Istanbul, Turkey.
⁵ Hospital Universitario La Paz, Madrid, Spain.
⁶ Quality Analytical Commission of Spanish Society of Clinical Chemistry (SEQC), Barcelona, Spain.
⁷ Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway.
⁸ Norwegian Organization for Quality Improvement of Laboratory Examinations (Noklus), Bergen, Norway.
⁹ Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway.

No abstract available

Keywords: EuBIVAS; analytical performance specification; biological variation; insulin.

References

1. Fraser, CG, Harris, EK. Generation and application of data on biological variation in clinical chemistry. Crit Rev Clin Lab Sci 1989;27:409–37. https://doi.org/10.3109/10408368909106595.
1. Wilcox, G. Insulin and insulin resistance. Clin Biochem Rev 2005;26:19–39.
1. Magkos, F, Wang, X, Mittendorfer, B. Metabolic actions of insulin in men and women. Nutrition 2010;26:686–93. https://doi.org/10.1016/j.nut.2009.10.013.
1. Aarsand, AK, Fernandez-Calle, P, Webster, C, Coskun, A, Gonzales-Lao, E, Diaz-Garzon, J, et al.. The EFLM biological variation database; 2019. Available from: https://biologicalvariation.eu [Accessed Sep 2020].
1. Eckfeldt, J, Chambless, L, Shen, Y. Short-term, within-person variability in clinical chemistry test results. Arch Pathol Lab Med 1994;118:496–500.